Co-amilofruse

Co-amilofruse (BAN) is a nonproprietary name used to denote a combination of amiloride and furosemide, which are both diuretics. Co-amilofruse is a treatment for fluid retention (oedema), either in the legs (peripheral edema) or on the lungs (pulmonary oedema). Furosemide is a loop diuretic and is more effective than amiloride, but has a tendency to cause low potassium levels (hypokalaemia); the potassium-sparing effects of amiloride may balance this.

Co-amilofruse

Combination of
Amiloride	Potassium-sparing diuretic
Furosemide	Loop diuretic
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C03EB01 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Identifiers
ChemSpider	none
(what is this?)  (verify)

Formulation

Two strengths of co-amilofruse are available:

• 2.5 mg amiloride with 20 mg furosemide, BAN of Co-amilofruse 2.5/20 (brand name Frumil LS)
• 5 mg amiloride with 40 mg furosemide, BAN of Co-amilofruse 5/4-0 (brand name Frumil)

References

• British National Formulary 2004