Chromatin target of prmt1

Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene.[3]

CHTOP
Identifiers
Aliases	CHTOP, C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704, chromatin target of PRMT1, C10orf77
External IDs	OMIM: 614206 HomoloGene: 134556 GeneCards: CHTOP
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,633,982 bp[1] End 153,646,306 bp[1]
Gene ontology Molecular function • methyl-CpG binding • GO:0001948 protein binding • RNA binding Cellular component • nuclear speck • nucleolus • transcription export complex • cell nucleus • nucleoplasm • cytoplasmic ribonucleoprotein granule Biological process • mRNA transport • regulation of transcription, DNA-templated • positive regulation of ATPase activity • positive regulation of helicase activity • positive regulation of histone methylation • transcription, DNA-templated • positive regulation of cell proliferation • RNA export from nucleus • termination of RNA polymerase II transcription • mRNA export from nucleus • mRNA 3'-end processing • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26097	n/a
Ensembl	ENSG00000160679	n/a
UniProt	Q9Y3Y2	n/a
RefSeq (mRNA)	NM_001206612 NM_001244664 NM_015607 NM_001317077	n/a
RefSeq (protein)	NP_001193541 NP_001231593 NP_001304006 NP_056422	n/a
Location (UCSC)	Chr 1: 153.63 – 153.65 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. The encoded protein may be involved in cell cycle progression. This protein interacts with protein arginine methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing results in multiple transcript variants.

References

1. GRCh38: Ensembl release 89: ENSG00000160679 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Chromatin target of PRMT1".

Further reading

• Zullo AJ, Michaud M, Zhang W, Grusby MJ (May 2009). "Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation". The Journal of Biological Chemistry. 284 (18): 12504–11. doi:10.1074/jbc.M809436200. PMC 2673316. PMID 19254951.
• Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA (February 2013). "Chtop is a component of the dynamic TREX mRNA export complex". The EMBO Journal. 32 (3): 473–86. doi:10.1038/emboj.2012.342. PMC 3567497. PMID 23299939.
• Teng IF, Wilson SA (2013). "Mapping interactions between mRNA export factors in living cells". PLOS ONE. 8 (6): e67676. Bibcode:2013PLoSO...867676T. doi:10.1371/journal.pone.0067676. PMC 3691119. PMID 23826332.
• van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S (January 2010). "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases". Molecular and Cellular Biology. 30 (1): 260–72. doi:10.1128/MCB.00645-09. PMC 2798285. PMID 19858291.
• van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S (November 2010). "Fetal globin expression is regulated by Friend of Prmt1". Blood. 116 (20): 4349–52. doi:10.1182/blood-2010-03-274399. PMC 2993632. PMID 20688955.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.