Charles S. Bryan

Charles Stone Bryan (born 1942) is an American retired infectious disease physician, researcher, author and Heyward Gibbes distinguished professor emeritus of internal medicine at the University of South Carolina School of Medicine (UofSC). His contributions to medicine have included working on a formula for administering the maximum possible dose of penicillin to people with kidney failure which would treat the infection and avoid penicillin toxicity, and treating and writing on HIV/AIDS. He is also a noted medical historian and an authority on the life of William Osler.

Charles S. Bryan

MD, MACP, FRCP
Bryan in May 2019
Born
Charles Stone Bryan

1942 (age 78–79)
NationalityAmerican
Education
OccupationProfessor of internal medicine
Known for
  • Research in infectious diseases
  • Literary contributions to internal medicine and history of medicine
Medical career
ProfessionPhysician and medical historian
InstitutionsUniversity of South Carolina School of Medicine (UofSC)
Research
AwardsOrder of the Palmetto (2013)

He is a Master of the American College of Physicians, and has been president of the South Carolina Infectious Diseases Society, the American Osler Society and the Columbia Medical Society. His awards include the American Osler Society's Lifetime Achievement Award in 2010 and the Order of the Palmetto in 2013.

Bryan's publications include Osler: Inspirations from a Great Physician (1997), Infectious Diseases in Primary Care (2002), and Asylum Doctor; James Woods Babcock and the Red Plague of Pellagra (2014), the result of 15 years of research.

Early life and education

Charles Bryan, known also as "Charley",[1] was born and brought up in Columbia, South Carolina,[2] and attended Dreher High School and then Harvard College.[3] His father was a physician and his mother was from Virginia.[2][4]

At Harvard, he spent some time under sociologist David Riesman and wrote on slavery on a South Carolina rice plantation. This became the start of Bryan's parallel career in medical history.[5]

In 1963, he transferred to the Johns Hopkins University School of Medicine, taking a copy of William Osler's inspirational addresses, Aequanimitas, given to him by his father.[3][4] Here, he approached historian David Donald and developed his slavery paper into a thesis and during one summer break, he worked on a project on bloodletting under historian Owsei Temkin.[5] In 1966, he received a traveling scholarship in the history of medicine by the University of Kansas. This took him to London where he continued further studies of bloodletting and also visited The Doctor by Luke Fildes at the Tate Gallery.[4]

In 1967 he completed his five years of medical education and received both a BA and MD.[3][6]

Career
Charles S. Bryan, Norham Gardens, Oxford (2020)

In 1974, he returned to Columbia after completing training at both the Johns Hopkins and the Vanderbilt University Medical Center and then entered private practice in internal medicine and infectious diseases. In 1977, he became a charter faculty member at the UofSC, where he has served as director of the Division of Infectious Diseases between 1977 and 1993, chair of the Department of Medicine between 1992 and 2000, and director of the Center for bioethics and medical humanities from 2000.[6]

In the early 1970s, Bryan and nephrologist Bill Stone worked out a formula for administering the maximum possible dose of penicillin to a person in kidney failure which would treat the infection while avoiding penicillin toxicity.[2][7][8]

He served as a hospital epidemiologist at a number of hospitals in the Columbia area. For the care of patients with HIV/AIDS, a disease Bryan has treated and written on and stressed the importance of understanding the social and historical context of,[9] he was the principal founder of the Midlands Care Consortium in South Carolina.[6] He also contributed to South Carolina's early response to the HIV/AIDS epidemic.[10]

As of 2019, he is preparing an encyclopedia of William Osler and his times.[11]

Honors and awards

Bryan is a master of the American College of Physicians, a fellow of the Royal College of Physicians of Edinburgh and Royal College of Physicians, London, a fellow the Infectious Diseases Society of America, a co-founder and past president of the South Carolina Infectious Diseases Society, and a past president of the Columbia Medical Society and of the Waring Library Society. He is a member of a number of medical organizations including the American Clinical and Climatological Association, the National Foundation for Infectious Diseases and the American Osler Society, of which he is a past president.[6][12]

Bryan is the recipient of a number of awards including;

In April 2012, Bryan was inducted into the Society of St. Luke at Providence Hospital, Columbia.[18] In 2013 he received the Order of the Palmetto.[16]

The Association of Professors of Medicine created the Charles S. Bryan Dinner in recognition of his contributions to that organization.[6] In 2002, a portrait of Bryan was completed by artist Tarleton Blackwell. It was based on a photograph taken in 1994, in Osler's study at 13 Norham Gardens, Oxford.[6] In 2003, the Charles S. Bryan History of Medicine Room at the UofSC was named in his honor,[3] and the same institution also created the Charles S. Bryan Scholar Award to recognize each year an outstanding internal medicine resident.[6] In 2017, the South Carolina chapter of the American College of Physicians created the Charles S. Bryan Lecture in the Humanities.[19]

Personal and family
Unveiling of portrait of Sir William Osler by Charle S. Bryan and his wife Donna. Taken in Oxford, 2020

Bryan is married to the former Donna Hennessee, who founded the Seeds of Hope Farmers Market Project in South Carolina.[20][21]

Selected publications

Bryan has authored a number of works on the pharmacology of antibiotics, bloodstream infections, and hospital-acquired infections as well as on the history of medicine, particularly relating to Sir William Osler, on whom he is considered an authority. He has made over 500 contributions to medical literature including writing 12 books.[1] In 2020, he led the creation of William Osler: An Encyclopedia.[22]

Books

His books include:

  • Osler: Inspirations from a Great Physician, Oxford University Press, 1997. ISBN 9780195112511[23][24]
  • Infectious Diseases in Primary Care, W. B. Saunders Company, 2002. ISBN 9780721690568[6]
  • The Quotable Osler, co-authored with Mark E. Silverman and T. J. Murray, American College of Physicians, 2008. ISBN 9781934465004[25][26]
  • Asylum Doctor; James Woods Babcock and the Red Plague of Pellagra, Waring Historical Library, Medical University of South Carolina, 2014. ISBN 978-1-61117-490-8 Details mental illness and pellagra in South Carolina.[1][27][28] In 2015, it was described as "probably his most ambitious undertaking, requiring as it did 15 years of painstaking research".[3]

Editor

Between 1977 and 2012, he was editor of the Journal of the South Carolina Medical Association and in addition he has reviewed for a number of other medical journals,[6] including Infection Control & Hospital Epidemiology.[29]

Articles

He has authored a landmark article on the over-prescribing of antibiotics.[16]

References
  1. "Distinguished Alumnus Award 2015 | Johns Hopkins Alumni". alumni.jhu.edu. Retrieved 16 May 2019.
  2. Roberts, William C. (1999). "Charles Stone Bryan, MD: a conversation with the editor" (PDF). Baylor University Medical Center Proceedings. 12 (4): 285–303. doi:10.1080/08998280.1999.11930199.
  3. Lathan, S. Robert (January 2015). "Asylum Doctor: James Woods Babcock and the Red Plague of Pellagra". Proceedings (Baylor University. Medical Center). 28 (1): 124–125. doi:10.1080/08998280.2015.11929210. ISSN 0899-8280. PMC 4264732.
  4. Bryan, Charles S. (2005). "Coping with the HIV/AIDs Epidemic". In Duffin, Jacalyn (ed.). Clio in the Clinic: History in Medical Practice. University of Toronto Press. pp. 73–82. ISBN 0802037984.
  5. Frierson, Lesley H. (2015). "The Recorder- An Interview with Charles S. Bryan" (PDF). Journal of the Columbia Medical Society. LXXXI: 8–12.
  6. Kane, Laura. "SOM Library: Charles S. Bryan History of Medicine Room: About Dr. Bryan". uscmed.sc.libguides.com. Retrieved 16 May 2019.
  7. Pazin, George J. (1 June 1976). "Penicillin Dose and Creatinine Clearance". Annals of Internal Medicine. 84 (6): 754. doi:10.7326/0003-4819-84-6-754_1. ISSN 0003-4819. PMID 937898.
  8. Betts, Robert F.; Penn, Robert L.; Chapman, Stanley W. (2003). Reese and Betts' a Practical Approach to Infectious Diseases. Lippincott Williams & Wilkins. ISBN 9780781732819.
  9. Belfiore, Eleonora; Upchurch, Anna (2013). Humanities in the Twenty-First Century: Beyond Utility and Markets. Palgrave Macmillan. p. 123. ISBN 9780230366633.
  10. Grauer, Neil A. (2016). "Philosophical Physician". www.hopkinsmedicine.org. Retrieved 19 May 2019.
  11. Bryan, Charles S. (2019). The Centenary of "The Old Humanities and the New Science," William Osler's Last Public Address (PDF). American Osler Society. p. 15.
  12. "American Osler - Home". www.americanosler.org. Retrieved 16 May 2019.
  13. S, L. G. (1 October 1967). "Awards". Journal of the History of Medicine and Allied Sciences. XXII (4): 420–421. doi:10.1093/jhmas/XXII.4.420. ISSN 0022-5045.(subscription required)
  14. "Winners of the Theodore E. Woodward Award". Transactions of the American Clinical and Climatological Association. 128: 158–159. 2017. ISSN 0065-7778. PMC 5525409.
  15. Bryan, Charles S.; Smith, Sabra; Ahuja, Divya (1 December 2009). "HIV/AIDS Ethics Education" (PDF). AMA Journal of Ethics. 11 (12): 953–957. doi:10.1001/virtualmentor.2009.11.12.medu2-0912. ISSN 2376-6980. PMID 23207089.
  16. "Centennial Legacy Award: South Carolina Chapter - Charles S. Bryan, MD, MACP, FRCP | Member Profiles | ACP". www.acponline.org. Retrieved 16 May 2019.
  17. "American Osler - Lifetime Achievement Awards" (PDF). www.americanosler.org. Retrieved 16 May 2019.
  18. Moss, Sandra (June 2012). "A message from the President" (PDF). The Oslerian. 13: 1.
  19. Bryan, Charles S. (21 October 2017). "The Charles S. Bryan Lecture in the Humanities; Osler then and now: Are the Humanities still the Hormones?" (PDF). American College of Physicians.
  20. "Donna Hennessee Bryan - South Carolina Legislature Online". www.scstatehouse.gov. Retrieved 18 April 2020.
  21. Bryan, Charles S. (1996). A Most Satisfactory Man: The Story of Theodore Brevard Hayne, Last Martyr of Yellow Fever. University of South Carolina Press. ISBN 9780871524966.
  22. "A Message from the President". The Oslerian. Vol. 20, Issue 4 (February 2020), p. 1-2.
  23. Edelson, Paul J. (1 December 1998). "Osler: Inspirations from a Great Physician. Charles S. Bryan". Isis. 89 (4): 751. doi:10.1086/384210. ISSN 0021-1753.
  24. Lu, Xiaoqin; Kahn, Richard J. (13 December 2016). "Osler: Inspirations from a Great Physician Charles S. Bryan". Canadian Bulletin of Medical History. 16: 390–392. doi:10.3138/cbmh.16.2.390.
  25. Burns, Chester R. (2004). "The Quotable Osler (review)". Bulletin of the History of Medicine. Johns Hopkins University Press. 78: 245–246. doi:10.1353/bhm.2004.0010. S2CID 71240594.
  26. Graner, John L. (September 2003). "The Quotable Osler". Mayo Clinic Proceedings. 78 (9): 1192. doi:10.4065/78.9.1190-a.
  27. Bryan, Charles S. "Asylum Doctor". www.sc.edu. Retrieved 16 May 2019.
  28. "The American South's Deadly Diet | DiscoverMagazine.com". Discover Magazine. Retrieved 16 May 2019.
  29. "1998 Reviewers". Infection Control & Hospital Epidemiology. 20 (5): 370. May 1999. doi:10.1017/S0195941700068685. ISSN 0899-823X.
  30. Noskin, Gary A.; Bolon, Maureen K.; Postelnick, Michael J.; Scheetz, Marc H.; Feinglass, Joe M.; Scarsi, Kimberly K. (2006-10-01). "Impact of Inactive Empiric Antimicrobial Therapy on Inpatient Mortality and Length of Stay". Antimicrobial Agents and Chemotherapy. 50 (10): 3355–3360. doi:10.1128/AAC.00466-06. ISSN 0066-4804. PMC 1610056. PMID 17005817.
  31. Warren, Beverlee; Warren, Timothy S. (January 2007). "For Goodness Sake: The Seven Basic Virtues by Charles S. Bryan, MD". Proceedings (Baylor University. Medical Center). 20 (1): 91–92. doi:10.1080/08998280.2007.11928251. ISSN 0899-8280. PMC 1769548.
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