Center for Human Reproduction

The Center for Human Reproduction (CHR) is a fertility center located in New York City and founded by the obstetrician-gynecologist Norbert Gleicher in 1981.[1][2][3]

Center for Human Reproduction
AbbreviationCHR
Formation1981 (1981)
FounderNorbert Gleicher
Founded atChicago, United States
Location
FieldsReproductive medicine

History

Creation and decade of 1980s

Norbert Gleicher, an obstetrician-gynecologist born in Kraków, moved to the United States to complete his fellowship in immunology in New York City and to develop his residency in obstetrics and gynecology at Mount Sinai Medical Center in Chicago. After holding positions as assistant professor in the Department of Obstetrics and Gynecology and division director of the division of Reproductive Immunology at the medical center, he founded the Center for Human Reproduction in Chicago in 1981, established as the first IVF center in the Midwest.[4] In 1983, the center performed worlds's first transvaginal egg retrieval. Five years later a manuscript was published reporting the world's first transvaginal tubal catheterization to open occluded fallopian tubes.[1][5]

1990's: New York City opening

With the growth of the center in Chicago, a new headquarters was opened in New York City.[3] In 1997, the center reached an agreement with Columbia University to staff CHR NY as university's IVF program. One year later, CHR NY opened at 635 Madison Avenue including in its staff the american physician Mark V. Sauer, who was then Head of the Reproductive Endocrinology Division at Columbia.[6] Sauer became the center's Medical Director and Dr. Andrea Vidali, also from Columbia University's division of reproductive endocrinology, was included in CHR's team of professionals. By the end of 1999, Gleicher was in charge of both centers in Chicago and New York City, splitting his time each week between the two cities.[1]

New millennium and present

In 2000, 21 E 69th Street location was purchased as the new site of CHR in New York City.[7] This location was opened on September 10, 2001, the night before the September 11 attacks. In 2003 Gleicher sold the Chicago operations to Reproductive Genetics Institute with a one-year transition period, and moved full-time back to New York City. That same year, David H. Barad, MD, MS, previously Head of Reproductive Endocrinology/IVF Division at Albert Einstein College of Medicine, joined the center as Clinical Director of Assisted Reproductive Technologies.[8] With the inclusion of Barad, the center's research focus on ovarian aging tightened.[9]

In 2005, CHR published the first manuscript on the use of DHEA supplementation for female fertility in Fertility & Sterility international journal.[10] CHR published in 2008 the first manuscript about the danger of preimplantation genetic screening after performing some analyses that proved the low effectiveness of this procedure in improving the chances of pregnancy in IVF.[11]

Around 2010, the center started a research collaboration with Aritro Sen, PhD's laboratory at University of Rochester Medical Center. This collaboration resulted in several publications related to the crucial roles androgens play in female fertility.[12][13] Three years later, the center published the first report of IVF success rate manipulation, leading to CDC and SART to update report guidelines to close a loophole.[14][15] In 2015 CHR established "What's My Fertility", an online risk screening tool for young women to detect risk of developing premature ovarian aging (POA) and associated infertility later in life.[16][17]

In 2017, the center reported the oldest pregnancy and live birth in an almost 48-year-old woman, after an IVF procedure with her own eggs.[5][18] In 2018 and 2019, CHR website won the eHealthcare Leadership Award in Best Healthcare Content, in Medical Practice/Outpatient Facility category.[19] During the COVID-19 outbreak in New York City in 2020, the center remained open for urgent fertility treatments.[20]

References
  1. Boncompagni, Tatiana (2019-01-18). "How Norbert Gleicher, Fertility Expert, Spends His Sundays". The New York Times. ISSN 0362-4331. Retrieved 2020-08-18.
  2. "Nurture vs Nature: Epigenetics, IVF and the Donor Egg". Parentology. Retrieved 2020-07-21.
  3. "Fertility clinics struggle with a growing number of abandoned embryos". NBC News. Retrieved 2020-07-21.
  4. "Norbert Gleicher, MD, FACOG, FACS". Endofound. 1969-12-31. Retrieved 2020-08-18.
  5. "Dr. Norbert Gleicher". New York Lifestyles Magazine. Retrieved 2020-08-18.
  6. "Interviews - Dr. Mark Sauer". PBS. Retrieved 2020-08-18.
  7. "Fertility Physicians in New York". Fertility Physicians Network. Retrieved 2020-08-18.
  8. "Dr. David Barad, MD – New York, NY". Doximity. Retrieved 2020-08-18.
  9. "Conversations at CHR: Study on PRP for Ovarian Rejuvenation". CHR. Retrieved 2020-08-18.
  10. Barad, David H.; Gleicher, Norbert (2005-09-01). "Increased oocyte production after treatment with dehydroepiandrosterone". Fertility and Sterility. 84 (3): 756.e1–756.e3. ISSN 0015-0282.
  11. Gleicher, Norbert; Weghofer, Andrea; Barad, David (2008-03-18). "Preimplantation genetic screening: "established" and ready for prime time?". Fertility and Sterility. 89 (4): 780–788. ISSN 1556-5653. PMID 18353323.
  12. "Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression". Proceedings of the National Academy of Sciences of the United States of America. 111 (8): 3008–3013. 2014-02-25. ISSN 1091-6490. PMC 3939860. PMID 24516121.
  13. Prizant, Hen; Gleicher, Norbert; Sen, Aritro (2014-09-01). "Androgen actions in the ovary: balance is key". Journal of Endocrinology. 222 (3): R141–R151. ISSN 0022-0795.
  14. "Effect of Embryo Banking on U.S. National Assisted Reproductive Technology Live Birth Rates". PLOS ONE. 11 (5): e0154620. 2016-05-09. ISSN 1932-6203. PMC 4861597. PMID 27159215.
  15. "CDC-reported assisted reproductive technology live-birth rates may mislead the public". Reproductive Biomedicine Online. 35 (2): 161–164. 2017-05-23. ISSN 1472-6491. PMID 28578895.
  16. "What's My Fertility Releases the First Screening for Premature Ovarian Aging". PR Newswire. Retrieved 2020-07-21.
  17. "This New Fertility Test Can Warn Women if They're Running Out of Eggs". Science Alert. Retrieved 2020-07-21.
  18. "New York City Fertility Center Reports 2 Oldest IVF Pregnancies Ever Reported in Medical Literature with Use of Patients' Own Eggs". 24-7 Press Release Newswire. Retrieved 2020-08-18.
  19. "Winners Best Healthcare Leadership Awards". eHealthcare Leadership Awards. Retrieved 2020-07-21.
  20. "Is getting pregnant "medically necessary" right now?". MIT Technology Review. Retrieved 2020-07-21.
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