Celeste Nelson

Celeste M. Nelson (born 21 August 1976)[1] is a Professor of Chemical and Biological Engineering and the Director of the Program in Engineering Biology at Princeton University.[2][4] She is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and was a finalist in the 2017 and 2018 Blavatnik Awards for Young Scientists.

Celeste Nelson
Nelson speaks at the World Economic Forum in 2017
Born
Celeste M. Nelson

(1976-08-21) August 21, 1976[1]
Colorado Springs, Colorado[1]
Alma materJohns Hopkins University (PhD)
Massachusetts Institute of Technology (SB)
AwardsTau Beta Pi
Phi Beta Kappa
Innovators Under 35
Sloan Research Fellowship
Blavatnik Award for Young Scientists
Scientific career
FieldsDevelopmental biology
Tissue engineering
Morphogenesis
Mechanobiology[2]
InstitutionsPrinceton University
Lawrence Berkeley National Laboratory
ThesisThe regulation of endothelial cell form and function by VE-cadherin (2003)
InfluencesMina Bissell[3]
Websitecmngroup.princeton.edu

Early life and education

Nelson was born in Colorado Springs, Colorado.[1] She became interested in biology as a teenager, but it wasn't until she spent time in a laboratory that she realised how much she enjoyed experiments.[5] She studied biology and chemical engineering at the Massachusetts Institute of Technology (MIT) and graduated in 1998.[6][7] Whilst at MIT Nelson was a member of the Tau Beta Pi engineering honour society and graduated in Phi Beta Kappa. Nelson moved to Johns Hopkins University School of Medicine for her graduate studies, working on biomedical engineering under the supervision of Christopher S. Chen.[1][8][6]

Research and career

Nelson was a postdoctoral research fellow at the Lawrence Berkeley National Laboratory (LBNL) where she worked alongside Mina J. Bissell in the Division of Life Sciences.[6][3] Whilst at LBNL Nelson was awarded the outstanding performance award. She completed a course in embryology at the Woods Hole Marine Biological Laboratory in 2007.[5] Nelson joined Princeton University as an Assistant Professor in 2007.[9] She was promoted to Associate Professor in 2012 and full Professor in 2016. Her research considers how cells within tissues integrate complicated biological systems spatially and dynamically. At Princeton Nelson leads the Tissue Morphodynamic Laboratory, which combines engineering, cell biology and developmental biology.[10][11]

She investigates the morphogenesis process that builds both the mammary gland and vertebrate lung. To interrogate the process by which organs generate their internal anatomies Nelson created a protocol to grow these structures in a laboratory.[12] She identified that during morphogenesis, long-range communication between individual cells within biological tissue determines the pattern formation. She identified several genes that are essential for branching tissue to properly develop and studied how they work together to coordinate the branching process.[12] She showed that the signals that initiate tissue branching can also act to reawaken certain tumours.[12] In 2018 she coordinated a Royal Society meeting on the mechanics of embryonic development.[13]

Awards and honors

Her awards and honors include:[7]

Selected publications

Her publications[2] include:

  • Tissue Morphogenesis: methods and protocols[23]
  • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment[24]
  • Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer[25]
  • Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation[26]

Personal life

Nelson is married with one child.[5]

References
  1. "CV" (PDF). cmngroup.princeton.edu. Retrieved 2020-01-28.
  2. Celeste Nelson publications indexed by Google Scholar
  3. "Bissell Lab". lbl.gov. Retrieved 2020-01-26.
  4. Celeste Nelson publications from Europe PubMed Central
  5. Anon (2016). "Cell scientist to watch – Celeste Nelson". Journal of Cell Science. 129 (21): 3961–3962. doi:10.1242/jcs.197509. ISSN 0021-9533.
  6. "Celeste Nelson". aiche.org. 2012-12-05. Retrieved 2020-01-26.
  7. "Celeste M. Nelson | Chemical and Biological Engineering". cbe.princeton.edu. Retrieved 2020-01-26.
  8. Nelson, Celeste M. (2003). The regulation of endothelial cell form and function by VE-cadherin (PhD thesis). OCLC 57583282.
  9. "Nelson Group -- Celeste". cmngroup.princeton.edu. Retrieved 2020-01-26.
  10. migradmin (2016-06-07). "Celeste M. Nelson". molbio.princeton.edu. Retrieved 2020-01-26.
  11. "Distinguished Lecture Celeste Nelson | Emergent Behaviors of Integrated Cellular Systems". ebics.net. Retrieved 2020-01-26.
  12. Anon. "Innovator Under 35: Celeste Nelson, 34". technologyreview.com. MIT Technology Review. Retrieved 2020-01-26.
  13. "Mechanics of development". royalsociety.org. London: Royal Society. Retrieved 2020-01-26.
  14. "Nelson, Celeste". packard.org. The David and Lucile Packard Foundation. Retrieved 2020-01-26.
  15. "Junior faculty awards recognize outstanding research and teaching". engineering.princeton.edu. School of Engineering and Applied Science. 2017-04-19. Retrieved 2020-01-26.
  16. "Winners: Allan P. Colburn Award for Excellence in Publications by a Young Member of the Institute". aiche.org. AIChE. Retrieved 2020-01-26.
  17. "Nelson Receives SEAS Distinguished Teacher Award | Chemical and Biological Engineering". cbe.princeton.edu. Retrieved 2020-01-26.
  18. Anon (2018-11-20). "Faculty commended for outstanding teaching". engineering.princeton.edu. School of Engineering and Applied Science. Retrieved 2020-01-26.
  19. "Faculty Scholars Program". HHMI.org. Retrieved 2020-01-26.
  20. "America's Top Young Researchers Named Finalists for 2017 Blavatnik National Awards for Young Scientists | Blavatnik Awards for Young Scientists". blavatnikawards.org. Retrieved 2020-01-26.
  21. "Announcing the 2018 Blavatnik National Awards Finalists | Blavatnik Awards for Young Scientists". blavatnikawards.org. Retrieved 2020-01-26.
  22. Anon (2019-09-24). "Faculty commended for outstanding teaching". engineering.princeton.edu. School of Engineering and Applied Science. Retrieved 2020-01-26.
  23. Nelson, Celeste (2015). Tissue Morphogenesis: methods and protocols. Springer. ISBN 978-1-4939-1163-9. OCLC 892847750.
  24. Nelson, Celeste M. (2004). "Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment". Developmental Cell. 6 (4): 483–495. doi:10.1016/S1534-5807(04)00075-9. PMID 15068789.
  25. Nelson, Celeste M. (2006). "Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer". Annual Review of Cell and Developmental Biology. 22: 287–309. doi:10.1146/annurev.cellbio.22.010305.104315. PMC 2933192. PMID 16824016.
  26. Nelson, Celeste M. (2005). "Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation". Seminars in Cancer Biology. 15 (5): 342–352. doi:10.1016/j.semcancer.2005.05.001. PMC 2933210. PMID 15963732.
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