Candidapepsin
Candidapepsin (EC 3.4.23.24, Candida albicans aspartic proteinase, Candida albicans carboxyl proteinase, Candida albicans secretory acid proteinase, Candida olea acid proteinase, Candida aspartic proteinase, Candida olea aspartic proteinase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin
| Candidapepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.24 | ||||||||
| CAS number | 69458-91-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This endopeptidase js present in yeast Candida albicans.
References
- Remold H, Fasold H, Staib F (October 1968). "Purification and characterization of a proteolytic enzyme from Candida albicans". Biochimica et Biophysica Acta (BBA) - Enzymology. 167 (2): 399–406. doi:10.1016/0005-2744(68)90219-2. PMID 5729955.
- Rüchel R (May 1981). "Properties of a purified proteinase from the yeast Candida albicans". Biochimica et Biophysica Acta (BBA) - Enzymology. 659 (1): 99–113. doi:10.1016/0005-2744(81)90274-6. PMID 7018586.
- Negi M, Tsuboi R, Matsui T, Ogawa H (July 1984). "Isolation and characterization of proteinase from Candida albicans: substrate specificity". The Journal of Investigative Dermatology. 83 (1): 32–6. doi:10.1111/1523-1747.ep12261656. PMID 6203988.
- Lott TJ, Page LS, Boiron P, Benson J, Reiss E (February 1989). "Nucleotide sequence of the Candida albicans aspartyl proteinase gene". Nucleic Acids Research. 17 (4): 1779. doi:10.1093/nar/17.4.1779. PMC 331855. PMID 2646602.
External links
- Candidapepsin at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.