CXXC1

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.[5][6][7]

CXXC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QMB, 3QMC, 3QMD, 3QMG, 3QMH, 3QMI
Identifiers
Aliases	CXXC1, 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP, CXXC finger protein 1
External IDs	OMIM: 609150 MGI: 1921572 HomoloGene: 32221 GeneCards: CXXC1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1 Start 50,282,343 bp[1] End 50,288,304 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E2 Start 74,216,124 bp[2] End 74,221,496 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • zinc ion binding • GO:0001948 protein binding • GO:0001158 core promoter proximal region sequence-specific DNA binding • histone methyltransferase activity (H3-K4 specific) • metal ion binding • unmethylated CpG binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nuclear matrix • nuclear speck • cell nucleus • nucleoplasm • histone methyltransferase complex • cytosol • Set1C/COMPASS complex Biological process • positive regulation of transcription, DNA-templated • IRE1-mediated unfolded protein response • histone H3-K4 methylation • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30827	74322
Ensembl	ENSG00000154832	ENSMUSG00000024560
UniProt	Q9P0U4	Q9CWW7
RefSeq (mRNA)	NM_001101654 NM_014593	NM_028868 NM_001378844
RefSeq (protein)	NP_001095124 NP_055408	NP_083144 NP_001365773
Location (UCSC)	Chr 18: 50.28 – 50.29 Mb	Chr 18: 74.22 – 74.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154832 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024560 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun. 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292.
6. Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1". Mol Cell Biol. 20 (6): 2108–2121. doi:10.1128/MCB.20.6.2108-2121.2000. PMC 110827. PMID 10688657.
7. "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)".

External links

• Human CXXC1 genome location and CXXC1 gene details page in the UCSC Genome Browser.
• Human SPP1 genome location and SPP1 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9P0U4 (CXXC-type zinc finger protein 1) at the PDBe-KB.

Further reading

• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Lee JH, Voo KS, Skalnik DG (2002). "Identification and characterization of the DNA binding domain of CpG-binding protein". J. Biol. Chem. 276 (48): 44669–44676. doi:10.1074/jbc.M107179200. PMID 11572867.
• Carlone DL, Skalnik DG (2001). "CpG binding protein is crucial for early embryonic development". Mol. Cell. Biol. 21 (22): 7601–7606. doi:10.1128/MCB.21.22.7601-7606.2001. PMC 99931. PMID 11604496.
• Lee JH, Skalnik DG (2003). "CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals". J. Biol. Chem. 277 (44): 42259–42267. doi:10.1074/jbc.M205054200. PMID 12200428.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Lee JH, Skalnik DG (2006). "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex". J. Biol. Chem. 280 (50): 41725–41731. doi:10.1074/jbc.M508312200. PMID 16253997.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Young SR, Skalnik DG (2007). "CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line". DNA Cell Biol. 26 (2): 80–90. doi:10.1089/dna.2006.0535. PMID 17328666.