CTDSP1

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.[5][6][7]

CTDSP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T9Z, 1TA0, 2GHQ, 2GHT, 3L0B, 3L0C, 3L0Y, 3PGL, 4YGY, 4YH1
Identifiers
Aliases	CTDSP1, NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1
External IDs	OMIM: 605323 MGI: 2654470 HomoloGene: 100834 GeneCards: CTDSP1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,398,256 bp[1] End 218,405,941 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C3 Start 74,391,509 bp[2] End 74,397,285 bp[2]
Gene ontology Molecular function • phosphatase activity • CTD phosphatase activity • GO:0001948 protein binding • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding Cellular component • extracellular exosome • cell nucleus • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • negative regulation of G1/S transition of mitotic cell cycle • negative regulation of protein phosphorylation • negative regulation of neurogenesis • protein dephosphorylation • negative regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	58190	227292
Ensembl	ENSG00000144579	ENSMUSG00000026176
UniProt	Q9GZU7	P58466
RefSeq (mRNA)	NM_001206878 NM_001206879 NM_021198 NM_182642	NM_153088
RefSeq (protein)	NP_001193807 NP_067021 NP_872580	NP_694728
Location (UCSC)	Chr 2: 218.4 – 218.41 Mb	Chr 1: 74.39 – 74.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CTDSP1 has been shown to interact with SNAI1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000144579 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026176 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". Journal of Human Genetics. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
6. Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
7. "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
8. Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

Further reading

• Marquet S, Lepage P, Hudson TJ, Musser JM, Schurr E (September 2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mammalian Genome. 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134. S2CID 11308779.
• Fernandes AO, Campagnoni CW, Kampf K, Feng JM, Handley VW, Schonmann V, et al. (February 2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system". Journal of Neuroscience Research. 75 (4): 461–71. doi:10.1002/jnr.10882. PMID 14743429. S2CID 29467544.
• Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN (January 2005). "Small CTD phosphatases function in silencing neuronal gene expression". Science. 307 (5709): 596–600. Bibcode:2005Sci...307..596Y. doi:10.1126/science.1100801. PMID 15681389. S2CID 39722809.
• Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". The Journal of Biological Chemistry. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.

External links

• Human CTDSP1 genome location and CTDSP1 gene details page in the UCSC Genome Browser.