CRISPLD2

Cysteine-rich secretory protein LCCL domain-containing 2 is a cysteine-rich secretory protein that in humans is encoded by the CRISPLD2 gene.[5][6]

CRISPLD2
Identifiers
Aliases	CRISPLD2, CRISP11, LCRISP2, cysteine rich secretory protein LCCL domain containing 2, LGL1
External IDs	OMIM: 612434 MGI: 1926142 HomoloGene: 41792 GeneCards: CRISPLD2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 84,819,985 bp[1] End 84,920,768 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 119,992,438 bp[2] End 120,052,793 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • glycosaminoglycan binding • heparin binding Cellular component • extracellular exosome • transport vesicle • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen • extracellular • extracellular matrix Biological process • extracellular matrix organization • face morphogenesis • lung development • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83716	78892
Ensembl	ENSG00000103196	ENSMUSG00000031825
UniProt	Q9H0B8	Q8BZQ2
RefSeq (mRNA)	NM_031476	NM_030209 NM_001310635
RefSeq (protein)	NP_113664	NP_001297564 NP_084485
Location (UCSC)	Chr 16: 84.82 – 84.92 Mb	Chr 8: 119.99 – 120.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It has been predicted or experimentally observed to interact with C1orf173.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103196 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031825 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. "Entrez Gene: CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2".
7. Liu F, Feng Y, Li Z, Pan C, Su Y, Yang R, Song L, Duan H, Deng N (2014). "Clinic-genomic association mining for colorectal cancer using publicly available datasets". Biomed Res Int. 2014: 170289. doi:10.1155/2014/170289. PMC 4060771. PMID 24987669.

External links

• Human CRISPLD2 genome location and CRISPLD2 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Chiquet BT, Lidral AC, Stal S, et al. (2008). "CRISPLD2: a novel NSCLP candidate gene". Hum. Mol. Genet. 16 (18): 2241–8. doi:10.1093/hmg/ddm176. PMC 3755375. PMID 17616516.