CRIPT

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.[5][6][7][8][9]

CRIPT
Identifiers
Aliases	CRIPT, SSMDF, HSPC139, CXXC repeat containing interactor of PDZ3 domain
External IDs	OMIM: 604594 MGI: 1929655 HomoloGene: 8572 GeneCards: CRIPT
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 46,616,416 bp[1] End 46,630,176 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 87,025,550 bp[2] End 87,035,810 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule binding • scaffold protein binding • PDZ domain binding • GO:0001948 protein binding • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • dendritic shaft • cell junction • neuronal cell body • dendritic spine • dendrite • cell projection • synapse • nucleolus • GO:0097483, GO:0097481 postsynaptic density • cell nucleus • fibrillar center Biological process • regulation of postsynaptic density protein 95 clustering • protein localization to microtubule • cytoplasmic microtubule organization • establishment of protein localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9419	56724
Ensembl	ENSG00000119878	ENSMUSG00000024146
UniProt	Q9P021	O70333
RefSeq (mRNA)	NM_014171	NM_019936
RefSeq (protein)	NP_054890	NP_064320
Location (UCSC)	Chr 2: 46.62 – 46.63 Mb	Chr 17: 87.03 – 87.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CRIPT has been shown to interact with DLG3.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000119878 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024146 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). "The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins". J Biochem. 138 (2): 177–82. doi:10.1093/jb/mvi107. PMID 16091592.
6. Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J Biol Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.
7. Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". Nat Neurosci. 2 (12): 1063–9. doi:10.1038/15990. PMID 10570482. S2CID 8145832.
8. Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.
9. "Entrez Gene: CRIPT cysteine-rich PDZ-binding protein".
10. Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. United States. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.
• Cai C, Coleman SK, Niemi K, Keinänen K (2002). "Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif". J. Biol. Chem. 277 (35): 31484–90. doi:10.1074/jbc.M204354200. PMID 12070168.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays". J. Am. Chem. Soc. 128 (17): 5913–22. doi:10.1021/ja060943h. PMC 2533859. PMID 16637659.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links

• Human CRIPT genome location and CRIPT gene details page in the UCSC Genome Browser.