CPSF3

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.[5][6]

CPSF3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3
External IDsOMIM: 606029 MGI: 1859328 HomoloGene: 6499 GeneCards: CPSF3
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p25.1Start9,423,651 bp[1]
End9,473,101 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51692

54451

Ensembl

ENSG00000119203

ENSMUSG00000054309

UniProt

Q9UKF6

Q9QXK7

RefSeq (mRNA)

NM_016207
NM_001321833
NM_001321834
NM_001321835
NM_001321836

NM_018813
NM_001364372
NM_001364373

RefSeq (protein)

NP_001308762
NP_001308763
NP_001308764
NP_001308765
NP_057291

NP_061283
NP_001351301
NP_001351302

Location (UCSC)Chr 2: 9.42 – 9.47 MbChr 12: 21.29 – 21.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Model organisms

Model organisms have been used in the study of CPSF3 function. A conditional knockout mouse line called Cpsf3tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]

References

  1. GRCh38: Ensembl release 89: ENSG00000119203 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054309 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W (Dec 1996). "Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I". Science. 274 (5292): 1514–7. doi:10.1126/science.274.5292.1514. PMID 8929409. S2CID 12958377.
  6. "Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa".
  7. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  8. "International Mouse Phenotyping Consortium".
  9. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  10. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  12. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  13. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading


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