CPLX1

Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.[5][6]

CPLX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RK3, 3RL0
Identifiers
Aliases	CPLX1, CPX-I, CPX1, complexin 1, EIEE63
External IDs	OMIM: 605032 MGI: 104727 HomoloGene: 21324 GeneCards: CPLX1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 784,957 bp[1] End 826,129 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 108,518,554 bp[2] End 108,550,024 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • syntaxin-1 binding • neurotransmitter transporter activity • syntaxin binding • SNARE binding • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • synapse • synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex • neuronal cell body • dendrite • SNARE complex • macromolecular complex • presynapse • calyx of Held • Schaffer collateral - CA1 synapse • postsynapse • glutamatergic synapse • terminal bouton Biological process • synaptic vesicle exocytosis • insulin secretion • regulation of exocytosis • neurotransmitter transport • exocytosis • chemical synaptic transmission • regulation of synaptic vesicle fusion to presynaptic active zone membrane • exocytic insertion of neurotransmitter receptor to postsynaptic membrane • vesicle-mediated transport in synapse • regulation of neurotransmitter secretion • GO:0010554 neurotransmitter secretion • glutamate secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10815	12889
Ensembl	ENSG00000168993	ENSMUSG00000033615
UniProt	O14810	P63040
RefSeq (mRNA)	NM_006651	NM_007756
RefSeq (protein)	NP_006642	NP_031782
Location (UCSC)	Chr 4: 0.78 – 0.83 Mb	Chr 5: 108.52 – 108.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.[6]

Interactions

CPLX1 has been shown to interact with SNAP-25[7][8] and STX1A.[9][7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000168993 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033615 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McMahon HT, Missler M, Li C, Südhof TC (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
6. "Entrez Gene: CPLX1 complexin 1".
7. Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227. S2CID 17878965.
8. Hu K, Carroll J, Rickman C, Davletov B (Nov 2002). "Action of complexin on SNARE complex". The Journal of Biological Chemistry. 277 (44): 41652–6. doi:10.1074/jbc.M205044200. PMID 12200427.
9. Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". The EMBO Journal. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.

External links

• Human CPLX1 genome location and CPLX1 gene details page in the UCSC Genome Browser.

Further reading

• Abe T (Jun 2002). "[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 47 (7): 794–800. PMID 12058476.
• Ishizuka T, Saisu H, Odani S, Abe T (Aug 1995). "Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals". Biochemical and Biophysical Research Communications. 213 (3): 1107–14. doi:10.1006/bbrc.1995.2241. PMID 7654227.
• Harrison PJ, Eastwood SL (Nov 1998). "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia". Lancet. 352 (9141): 1669–73. doi:10.1016/S0140-6736(98)03341-8. PMID 9853440. S2CID 45239545.
• Ishizuka T, Saisu H, Odani S, Kumanishi T, Abe T (Jan 1999). "Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex". Neuroscience. 88 (1): 295–306. doi:10.1016/S0306-4522(98)00223-1. PMID 10051208. S2CID 46636775.
• Eastwood SL, Cotter D, Harrison PJ (2001). "Cerebellar synaptic protein expression in schizophrenia". Neuroscience. 105 (1): 219–29. doi:10.1016/S0306-4522(01)00141-5. PMID 11483314. S2CID 34257327.
• Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227. S2CID 17878965.
• Sawada K, Young CE, Barr AM, Longworth K, Takahashi S, Arango V, Mann JJ, Dwork AJ, Falkai P, Phillips AG, Honer WG (2002). "Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness". Molecular Psychiatry. 7 (5): 484–92. doi:10.1038/sj.mp.4000978. PMID 12082566.
• Basso M, Giraudo S, Corpillo D, Bergamasco B, Lopiano L, Fasano M (Dec 2004). "Proteome analysis of human substantia nigra in Parkinson's disease". Proteomics. 4 (12): 3943–52. doi:10.1002/pmic.200400848. hdl:11383/1491905. PMID 15526345. S2CID 23119746.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Giraudo CG, Eng WS, Melia TJ, Rothman JE (Aug 2006). "A clamping mechanism involved in SNARE-dependent exocytosis". Science. 313 (5787): 676–80. doi:10.1126/science.1129450. PMID 16794037. S2CID 28309295.