COPS7B

COP9 signalosome complex subunit 7b is a protein that in humans is encoded by the COPS7B gene.[5][6]

COPS7B
Identifiers
Aliases	COPS7B, CSN7B, SGN7b, COP9 signalosome subunit 7B
External IDs	OMIM: 616010 MGI: 1349388 HomoloGene: 8068 GeneCards: COPS7B
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,781,671 bp[1] End 231,809,254 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 43.97 cM Start 86,582,904 bp[2] End 86,609,375 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • COP9 signalosome • cell nucleus • nucleoplasm • cytosol Biological process • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA damage recognition • protein deneddylation • post-translational modification • GO:0022415 viral process • COP9 signalosome assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64708	26895
Ensembl	ENSG00000144524	ENSMUSG00000026240
UniProt	Q9H9Q2	Q8BV13
RefSeq (mRNA)	NM_001282949 NM_001282950 NM_001282951 NM_001282952 NM_001308381 NM_022730 NM_001369483	NM_172974 NM_001360887 NM_001360888
RefSeq (protein)	NP_001269878 NP_001269879 NP_001269880 NP_001269881 NP_001295310 NP_073567 NP_001356412	NP_766562 NP_001347816 NP_001347817
Location (UCSC)	Chr 2: 231.78 – 231.81 Mb	Chr 1: 86.58 – 86.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000144524 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026240 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (Oct 1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402. S2CID 13873982.
6. "Entrez Gene: COPS7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)".

External links

• Human COPS7B genome location and COPS7B gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
• Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588. S2CID 14224920.
• Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626. S2CID 39308598.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
• Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143. S2CID 11639677.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.