COG8

Conserved oligomeric Golgi complex subunit 8 is a protein that in humans is encoded by the COG8 gene.[4][5]

COG8
Identifiers
AliasesCOG8, CDG2H, DOR1, component of oligomeric golgi complex 8
External IDsOMIM: 606979 MGI: 2142885 HomoloGene: 13018 GeneCards: COG8
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q22.1Start69,320,140 bp[1]
End69,339,667 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84342

97484

Ensembl

ENSG00000213380

ENSMUSG00000031916

UniProt

Q96MW5

Q9JJA2

RefSeq (mRNA)

NM_032382
NM_001374871

NM_139229

RefSeq (protein)

NP_115758

NP_631975

Location (UCSC)Chr 16: 69.32 – 69.34 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi complex (COG), which includes COG8 (Ungar et al., 2002).[supplied by OMIM][5]

References

  1. GRCh38: Ensembl release 89: ENSG00000213380 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  5. "Entrez Gene: COG8 component of oligomeric golgi complex 8".

Further reading


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