COG1

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.[5][6]

COG1
Identifiers
Aliases	COG1, CDG2G, LDLB, component of oligomeric golgi complex 1
External IDs	OMIM: 606973 MGI: 1333873 HomoloGene: 8411 GeneCards: COG1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 73,192,632 bp[1] End 73,208,507 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 113,649,169 bp[2] End 113,667,054 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • Golgi membrane • Golgi apparatus • membrane • trans-Golgi network membrane • Golgi transport complex Biological process • protein transport • ER to Golgi vesicle-mediated transport • intra-Golgi vesicle-mediated transport • Golgi organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9382	16834
Ensembl	ENSG00000166685	ENSMUSG00000018661
UniProt	Q8WTW3	Q9Z160
RefSeq (mRNA)	NM_018714	NM_013581
RefSeq (protein)	NP_061184	NP_038609
Location (UCSC)	Chr 17: 73.19 – 73.21 Mb	Chr 11: 113.65 – 113.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.[6]

Interactions

COG1 has been shown to interact with COG4[7] and COG3.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000166685 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018661 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A. 96 (3): 915–20. Bibcode:1999PNAS...96..915C. doi:10.1073/pnas.96.3.915. PMC 15325. PMID 9927668.
6. "Entrez Gene: COG1 component of oligomeric golgi complex 1".
7. Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. United States. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
8. Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. United States. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.

Further reading

• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
• Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ungar D, Oka T, Vasile E, et al. (2005). "Subunit architecture of the conserved oligomeric Golgi complex". J. Biol. Chem. 280 (38): 32729–35. doi:10.1074/jbc.M504590200. PMID 16020545.
• Vasile E, Oka T, Ericsson M, et al. (2006). "IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex". Exp. Cell Res. 312 (16): 3132–41. doi:10.1016/j.yexcr.2006.06.005. PMID 16857184.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
• Human COG1 genome location and COG1 gene details page in the UCSC Genome Browser.