COASY

Bifunctional coenzyme A synthase is an enzyme that in humans is encoded by the COASY gene.[5][6][7]

COASY
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOASY, DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2, Coenzyme A synthase, PCH12
External IDsOMIM: 609855 MGI: 1918993 HomoloGene: 11889 GeneCards: COASY
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.2Start42,561,467 bp[1]
End42,566,277 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80347

71743

Ensembl

ENSG00000068120

ENSMUSG00000001755

UniProt

Q13057

Q9DBL7

RefSeq (mRNA)

NM_001042529
NM_001042530
NM_001042531
NM_001042532
NM_025233

NM_027896
NM_001305982

RefSeq (protein)

NP_001035994
NP_001035997
NP_079509

NP_001292911

Location (UCSC)Chr 17: 42.56 – 42.57 MbChr 11: 101.08 – 101.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

COASY has been shown to interact with P70-S6 Kinase 1.[8] In 2009, COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000068120 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001755 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crécy-Lagard V, Osterman A (June 2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics". The Journal of Biological Chemistry. 277 (24): 21431–9. doi:10.1074/jbc.M201708200. PMID 11923312.
  6. Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT (June 2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis". The Journal of Biological Chemistry. 277 (25): 22107–10. doi:10.1074/jbc.C200195200. PMID 11980892.
  7. "Entrez Gene: COASY Coenzyme A synthase".
  8. Nemazanyy I, Panasyuk G, Zhyvoloup A, Panayotou G, Gout IT, Filonenko V (December 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Letters. 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. PMID 15589845. S2CID 9916948.
  9. Breus O, Panasyuk G, Gout IT, Filonenko V, Nemazanyy I (August 2009). "CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway". Biochemical and Biophysical Research Communications. 385 (4): 581–5. doi:10.1016/j.bbrc.2009.05.102. PMID 19482007.

Further reading


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