CLEC2B

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.[3][4]

CLEC2B
Identifiers
Aliases	CLEC2B, AICL, CLECSF2, HP10085, IFNRG1, C-type lectin domain family 2 member B
External IDs	OMIM: 603242 HomoloGene: 68443 GeneCards: CLEC2B
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 9,852,984 bp[1] End 9,870,136 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • carbohydrate binding • identical protein binding Cellular component • cell membrane • integral component of plasma membrane • integral component of membrane • membrane Biological process • regulation of immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9976	n/a
Ensembl	ENSG00000110852	n/a
UniProt	Q92478	n/a
RefSeq (mRNA)	NM_005127	n/a
RefSeq (protein)	NP_005118	n/a
Location (UCSC)	Chr 12: 9.85 – 9.87 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) protein superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length nucleotide sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000110852 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA (Mar 1997). "AICL: a new activation-induced antigen encoded by the human NK gene complex". Immunogenetics. 45 (5): 295–300. doi:10.1007/s002510050208. PMID 9038101. S2CID 34214844.
4. "Entrez Gene: CLEC2B C-type lectin domain family 2, member B".

External links

• Human CLEC2B genome location and CLEC2B gene details page in the UCSC Genome Browser.

Further reading

• Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048. S2CID 30955198.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Renedo M, Arce I, Montgomery K, et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2". Genomics. 65 (2): 129–36. doi:10.1006/geno.2000.6163. PMID 10783260.
• Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.