CHD5

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.[5][6][7] It is a part of the CHD subfamily of ATP-dependent chromatin remodeling complexes.

CHD5
Identifiers
Aliases	CHD5, CHD-5, chromodomain helicase DNA binding protein 5
External IDs	OMIM: 610771 MGI: 3036258 HomoloGene: 56712 GeneCards: CHD5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,101,787 bp[1] End 6,180,321 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 152,338,651 bp[2] End 152,390,194 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • nucleotide binding • GO:0008026 helicase activity • metal ion binding • H3K27me3 modified histone binding • hydrolase activity • ATP binding Cellular component • NuRD complex • membrane • heterochromatin • cell nucleus • nucleoplasm • cytosol • nuclear speck Biological process • cell differentiation • regulation of transcription, DNA-templated • spermatogenesis, exchange of chromosomal proteins • histone H3-K27 trimethylation • positive regulation of signal transduction by p53 class mediator • transcription, DNA-templated • nervous system development • regulation of transcription involved in cell fate commitment • spermatogenesis • histone H4 acetylation • cerebral cortex neuron differentiation • negative regulation of cell proliferation • covalent chromatin modification • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26038	269610
Ensembl	ENSG00000116254	ENSMUSG00000005045
UniProt	Q8TDI0	A2A8L1
RefSeq (mRNA)	NM_015557	NM_001081376 NM_029216 NM_001369243
RefSeq (protein)	NP_056372	NP_001074845 NP_083492 NP_001356172
Location (UCSC)	Chr 1: 6.1 – 6.18 Mb	Chr 4: 152.34 – 152.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000116254 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005045 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561. S2CID 1694959.
6. Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
7. "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

External links

• Human CHD5 genome location and CHD5 gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Bagchi A, Papazoglu C, Wu Y, et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell. 128 (3): 459–75. doi:10.1016/j.cell.2006.11.052. PMID 17289567. S2CID 13437928.