CHAF1B

Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.[5][6][7]

CHAF1B
Identifiers
AliasesCHAF1B, CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7, chromatin assembly factor 1 subunit B
External IDsOMIM: 601245 MGI: 1314881 HomoloGene: 48346 GeneCards: CHAF1B
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.12-q22.13Start36,385,392 bp[1]
End36,419,015 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8208

110749

Ensembl

ENSG00000159259

ENSMUSG00000022945

UniProt

Q13112

Q9D0N7

RefSeq (mRNA)

NM_005441

NM_028083

RefSeq (protein)

NP_005432

NP_082359

Location (UCSC)Chr 21: 36.39 – 36.42 MbChr 16: 93.88 – 93.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.[7]

Interactions

CHAF1B has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000159259 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022945 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kaufman PD, Kobayashi R, Kessler N, Stillman B (Jun 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell. 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578. S2CID 13502921.
  6. Katsanis N, Fisher EM (Oct 1996). "The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome". Human Genetics. 98 (4): 497–9. doi:10.1007/s004390050246. PMID 8792829. S2CID 1206979.
  7. "Entrez Gene: CHAF1B chromatin assembly factor 1, subunit B (p60)".
  8. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
  9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  10. Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/s0092-8674(03)00436-7. PMID 12837248.

Further reading

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