CENTD2

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.[5]

ARAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X1V
Identifiers
Aliases	ARAP1, CENTD2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
External IDs	OMIM: 606646 MGI: 1916960 HomoloGene: 12326 GeneCards: ARAP1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,685,069 bp[1] End 72,793,599 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,348,067 bp[2] End 101,412,586 bp[2]
Gene ontology Molecular function • metal ion binding • GO:0001948 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • phosphatidylinositol-3,4,5-trisphosphate binding • type 1 angiotensin receptor binding Cellular component • cytoplasm • Golgi apparatus • membrane • Golgi cisterna membrane • trans-Golgi network • cytoplasmic vesicle • nucleoplasm • cytosol • cell membrane • intracellular membrane-bounded organelle Biological process • actin filament reorganization involved in cell cycle • regulation of cell shape • regulation of cellular component movement • negative regulation of stress fiber assembly • regulation of small GTPase mediated signal transduction • positive regulation of filopodium assembly • signal transduction • positive regulation of receptor recycling • positive regulation of epidermal growth factor receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116985	69710
Ensembl	ENSG00000186635	ENSMUSG00000032812
UniProt	Q96P48	Q4LDD4
RefSeq (mRNA)	NM_015242 NM_001040118 NM_001135190 NM_001369489	NM_001040111 NM_001040112 NM_027180 NM_198096
RefSeq (protein)	NP_001035207 NP_001128662 NP_056057 NP_001356418	NP_001035200 NP_001035201 NP_081456 NP_932764
Location (UCSC)	Chr 11: 72.69 – 72.79 Mb	Chr 7: 101.35 – 101.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000186635 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032812 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CENTD2 centaurin, delta 2".

External links

• Human ARAP1 genome location and ARAP1 gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (January 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Molecular Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
• Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA (January 2002). "ARAP1: a point of convergence for Arf and Rho signaling". Molecular Cell. 9 (1): 109–19. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
• Ahn J, Chung KS, Kim DU, Won M, Kim L, Kim KS, Nam M, Choi SJ, Kim HC, Yoon M, Chae SK, Hoe KL (November 2004). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". Journal of Biochemistry and Molecular Biology. 37 (6): 741–8. doi:10.5483/bmbrep.2004.37.6.741. PMID 15607035.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.