CDCA5

Sororin is a protein that in humans is encoded by the CDCA5 gene.[5][6][7]

CDCA5
Identifiers
Aliases	CDCA5, SORORIN, cell division cycle associated 5
External IDs	OMIM: 609374 MGI: 1915099 HomoloGene: 49860 GeneCards: CDCA5
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,066,300 bp[1] End 65,084,164 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,084,983 bp[2] End 6,091,777 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • chromatin binding • GO:0001948 protein binding • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • cytosol • cohesin complex • chromosome • nucleoplasm • nuclear chromatin • chromatin • chromosome, centromeric region • cell nucleus Biological process • mitotic chromosome condensation • positive regulation of exit from mitosis • regulation of cohesin loading • cell division • mitotic sister chromatid cohesion • double-strand break repair • cell cycle • mitotic metaphase plate congression • GO:0007067 mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	113130	67849
Ensembl	ENSG00000146670	ENSMUSG00000024791
UniProt	Q96FF9	Q9CPY3
RefSeq (mRNA)	NM_080668	NM_026410
RefSeq (protein)	NP_542399	NP_080686
Location (UCSC)	Chr 11: 65.07 – 65.08 Mb	Chr 19: 6.08 – 6.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.[8]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000146670 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024791 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
6. Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
7. "Entrez Gene: CDCA5 cell division cycle associated 5".
8. Schmitz, J.; Watrin, E.; Lénárt, P.; Mechtler, K.; Peters, JM. (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791. S2CID 11988060.
9. Nguyen, MH.; Koinuma, J.; Ueda, K.; Ito, T.; Tsuchiya, E.; Nakamura, Y.; Daigo, Y. (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Res. 70 (13): 5337–47. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

External links

• Human CDCA5 genome location and CDCA5 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Schmitz J, Watrin E, Lénárt P, et al. (2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr. Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791. S2CID 11988060.
• Díaz-Martínez LA, Giménez-Abián JF, Clarke DJ (2007). "Regulation of centromeric cohesion by sororin independently of the APC/C". Cell Cycle. 6 (6): 714–24. doi:10.4161/cc.6.6.3935. PMID 17361102.