CCT8

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene.[5][6] The CCT8 protein is a component of the TRiC complex.

CCT8
Identifiers
Aliases	CCT8, C21orf112, Cctq, D21S246, PRED71, chaperonin containing TCP1 subunit 8
External IDs	OMIM: 617786 MGI: 107183 HomoloGene: 4802 GeneCards: CCT8
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 29,055,805 bp[1] End 29,073,797 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 87,483,326 bp[2] End 87,495,873 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • ATP binding • protein binding involved in protein folding • unfolded protein binding • cadherin binding Cellular component • cell body • cytosol • centrosome • cell projection • cilium • nucleoplasm • microtubule organizing center • zona pellucida receptor complex • intermediate filament cytoskeleton • microtubules • extracellular exosome • cytoskeleton • cytoplasm • chaperonin-containing T-complex • extracellular region • secretory granule lumen • azurophil granule lumen • ficolin-1-rich granule lumen Biological process • positive regulation of protein localization to Cajal body • positive regulation of establishment of protein localization to telomere • pore complex assembly • protein stabilization • positive regulation of telomere maintenance via telomerase • toxin transport • positive regulation of telomerase RNA localization to Cajal body • binding of sperm to zona pellucida • protein folding • 'de novo' protein folding • neutrophil degranulation • chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10694	12469
Ensembl	ENSG00000156261	ENSMUSG00000025613
UniProt	P50990	P42932
RefSeq (mRNA)	NM_006585 NM_001282907 NM_001282908 NM_001282909	NM_009840
RefSeq (protein)	NP_001269836 NP_001269837 NP_001269838 NP_006576	NP_033970
Location (UCSC)	Chr 21: 29.06 – 29.07 Mb	Chr 16: 87.48 – 87.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000156261 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025613 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kubota H, Hynes G, Willison K (Apr 1995). "The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1". Gene. 154 (2): 231–6. doi:10.1016/0378-1119(94)00880-2. PMID 7890169.
6. "Entrez Gene: CCT8 chaperonin containing TCP1, subunit 8 (theta)".

External links

• Human CCT8 genome location and CCT8 gene details page in the UCSC Genome Browser.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Yamazaki M, Ono A, Watanabe K, et al. (1996). "Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21". DNA Res. 2 (4): 187–9. doi:10.1093/dnares/2.4.187. PMID 8590283.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Hynes GM, Willison KR (2000). "Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin". J. Biol. Chem. 275 (25): 18985–94. doi:10.1074/jbc.M910297199. PMID 10748209.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.