CCT4

T-complex protein 1 subunit delta is a protein that in humans is encoded by the CCT4 gene.[4][5] The CCT4 protein is a component of the TRiC complex.

CCT4
Identifiers
Aliases	CCT4, CCT-DELTA, Cctd, SRB, chaperonin containing TCP1 subunit 4
External IDs	OMIM: 605142 MGI: 104689 HomoloGene: 4695 GeneCards: CCT4
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p15 Start 61,868,085 bp[1] End 61,888,671 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • ATP binding • protein binding involved in protein folding • unfolded protein binding • RNA binding Cellular component • cell body • centrosome • cell projection • melanosome • nucleoplasm • microtubule organizing center • zona pellucida receptor complex • chaperonin-containing T-complex • microtubules • extracellular exosome • cytoskeleton • cytoplasm • cytosol Biological process • positive regulation of protein localization to Cajal body • positive regulation of establishment of protein localization to telomere • scaRNA localization to Cajal body • protein stabilization • positive regulation of telomere maintenance via telomerase • toxin transport • protein folding • positive regulation of telomerase activity • positive regulation of telomerase RNA localization to Cajal body • binding of sperm to zona pellucida • 'de novo' protein folding • chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10575	12464
Ensembl	ENSG00000115484	ENSMUSG00000007739
UniProt	P50991	P80315
RefSeq (mRNA)	NM_006430 NM_001256721	NM_009837
RefSeq (protein)	NP_001243650 NP_006421	NP_033967
Location (UCSC)	Chr 2: 61.87 – 61.89 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CCT4 has been shown to interact with PPP4C.[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000115484 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.
5. "Entrez Gene: CCT4 chaperonin containing TCP1, subunit 4 (delta)".
6. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
7. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. S2CID 7531012.

External links

• Human CCT4 genome location and CCT4 gene details page in the UCSC Genome Browser.

Further reading

• Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530. S2CID 31300131.
• Wu-Baer F, Lane WS, Gaynor RB (Feb 1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". The Journal of Biological Chemistry. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763.
• Nabetani A, Hatada I, Morisaki H, Mukai T (Jun 1996). "Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11". Genomics. 34 (2): 246–9. doi:10.1006/geno.1996.0276. PMID 8661059. Check date values in: |year= / |date= mismatch (help)
• Melki R, Batelier G, Soulié S, Williams RC (May 1997). "Cytoplasmic chaperonin containing TCP-1: structural and functional characterization". Biochemistry. 36 (19): 5817–26. doi:10.1021/bi962830o. PMID 9153422.
• Llorca O, McCormack EA, Hynes G, Grantham J, Cordell J, Carrascosa JL, Willison KR, Fernandez JJ, Valpuesta JM (Dec 1999). "Eukaryotic type II chaperonin CCT interacts with actin through specific subunits". Nature. 402 (6762): 693–6. doi:10.1038/45294. PMID 10604479. S2CID 4421057. Check date values in: |year= / |date= mismatch (help)
• Llorca O, Martín-Benito J, Gómez-Puertas P, Ritco-Vonsovici M, Willison KR, Carrascosa JL, Valpuesta JM (Aug 2001). "Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". Journal of Structural Biology. 135 (2): 205–18. doi:10.1006/jsbi.2001.4359. PMID 11580270. Check date values in: |year= / |date= mismatch (help)
• Parissi V, Calmels C, De Soultrait VR, Caumont A, Fournier M, Chaignepain S, Litvak S (Dec 2001). "Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60". Journal of Virology. 75 (23): 11344–53. doi:10.1128/JVI.75.23.11344-11353.2001. PMC 114720. PMID 11689615.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563. Check date values in: |year= / |date= mismatch (help)
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270. Check date values in: |year= / |date= mismatch (help)
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065. Check date values in: |year= / |date= mismatch (help)