CCDC85B

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.[5][6][7]

CCDC85B
Identifiers
Aliases	CCDC85B, DIPA, coiled-coil domain containing 85B
External IDs	OMIM: 605360 MGI: 2147607 HomoloGene: 4989 GeneCards: CCDC85B
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,890,673 bp[1] End 65,891,635 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,453,180 bp[2] End 5,457,894 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • centrosome • cytoskeleton • cell nucleus • microtubule organizing center Biological process • regulation of growth • cell differentiation • negative regulation of fat cell differentiation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of cell growth • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11007	240514
Ensembl	ENSG00000175602	ENSMUSG00000095098
UniProt	Q15834	Q6PDY0
RefSeq (mRNA)	NM_006848	NM_001243307 NM_198616
RefSeq (protein)	NP_006839	NP_001230236 NP_941018
Location (UCSC)	Chr 11: 65.89 – 65.89 Mb	Chr 19: 5.45 – 5.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro.[7]

Interactions

CCDC85B has been shown to interact with:

• C19orf25,[8]
• KIAA1267,[8]
• Keratin 17,[8] and
• Protein kinase N1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000175602 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000095098 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brazas R, Ganem D (Oct 1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution". Science. 274 (5284): 90–4. doi:10.1126/science.274.5284.90. PMID 8810253. S2CID 20743492.
6. Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, Ailhaud G, Amri EZ (Mar 2005). "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of Biological Chemistry. 280 (12): 11432–8. doi:10.1074/jbc.M411741200. PMID 15644333.
7. "Entrez Gene: CCDC85B coiled-coil domain containing 85B".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Human CCDC85B genome location and CCDC85B gene details page in the UCSC Genome Browser.

Further reading

• Robertson HD (Oct 1996). "How did replicating and coding RNAs first get together?". Science. 274 (5284): 66–7. doi:10.1126/science.274.5284.66. PMID 8848724. S2CID 37715470.
• Long M, de Souza SJ, Gilbert W (May 1997). "Delta-interacting protein A and the origin of hepatitis delta antigen". Science. 276 (5313): 824–5. doi:10.1126/science.276.5313.824. PMID 9115212.
• Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, Conradt B, Shaham S (Feb 2005). "C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage". Cell Death and Differentiation. 12 (2): 153–61. doi:10.1038/sj.cdd.4401539. PMID 15605074.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.