CCDC80

Coiled-coil domain-containing protein 80 is a protein that in humans is encoded by the CCDC80 gene.[5][6][7] Bioinformatics analysis suggests the CCDC80 protein is a peroxiredoxin.[8]

CCDC80
Identifiers
Aliases	CCDC80, DRO1, SSG1, URB, okuribin, coiled-coil domain containing 80, CL2, LINC01279
External IDs	OMIM: 608298 MGI: 1915146 HomoloGene: 12206 GeneCards: CCDC80
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.2 Start 112,596,794 bp[1] End 112,649,530 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 45,093,402 bp[2] End 45,128,077 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • fibronectin binding • glycosaminoglycan binding • heparin binding Cellular component • extracellular region • basement membrane • interstitial matrix • extracellular matrix Biological process • extracellular matrix organization • positive regulation of cell-substrate adhesion • response to bacterium Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151887	67896
Ensembl	ENSG00000091986	ENSMUSG00000022665
UniProt	Q76M96	Q8R2G6
RefSeq (mRNA)	NM_199512 NM_199511	NM_026439
RefSeq (protein)	NP_955805 NP_955806	NP_080715
Location (UCSC)	Chr 3: 112.6 – 112.65 Mb	Chr 16: 45.09 – 45.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000091986 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022665 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonaldo MF, Lennon G, Soares MB (May 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
6. Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. PMID 15325258.
7. "Entrez Gene: CCDC80 coiled-coil domain containing 80".
8. Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

External links

• Human CCDC80 genome location and CCDC80 gene details page in the UCSC Genome Browser.

Further reading

• Okada T, Nishizawa H, Kurata A, et al. (2008). "URB is abundantly expressed in adipose tissue and dysregulated in obesity". Biochem. Biophys. Res. Commun. 367 (2): 370–6. doi:10.1016/j.bbrc.2007.12.164. PMID 18178152.
• Cha SY, Sung YK, Im S, et al. (2005). "URB expression in human dermal papilla cells". J. Dermatol. Sci. 39 (2): 128–30. doi:10.1016/j.jdermsci.2005.05.005. PMID 15998583.
• Bommer GT, Jäger C, Dürr EM, et al. (2005). "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells". J. Biol. Chem. 280 (9): 7962–75. doi:10.1074/jbc.M412593200. PMID 15563452.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aoki K, Sun YJ, Aoki S, et al. (2002). "Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3". Biochem. Biophys. Res. Commun. 290 (4): 1282–8. doi:10.1006/bbrc.2002.6337. PMID 11812002.