CCDC11
Coiled-Coil Domain Containing 11, also known as CCDC11 is a protein that is encoded by CCDC11 gene located at chromosome 18 in humans.[1]
Overview
The CCDC11 gene is located on chromosome 18q21.1 and is made of 39303 BP.[2] The CCDC11 protein is made of 514 amino acids and has a mass of 61835 Da.[2] Its aliases include coiled-coil domain containing protein 11, FLJ32743, OTTHUMP00000163503.[2]
Homology
CCDC has orthologs all the way back to betaproteobacteria which is a class of Proteobacteria.[2] The following table represents a small selection of orthologs found using searches in BLAST and BLAT. This is by no means a comprehensive list; however, it shows the diversity of species that CCDC11 is found.
| Species | Organism Common Name | NCBI Accession | Length (AAs) | Sequence Identity | Sequence Similarity |
| Homo sapiens | Human | NP_659457 | 514 | 100% | 100% |
| Pan troglodytes | Chimpanzee | XP_523923.3 | 514 | 99% | 99% |
| Callithrix jacchus | Marmoset | XP_002757278.1 | 514 | 92% | 95% |
| Ailuropoda melanoleuca | Panda | XP_002939158.1 | 514 | 83% | 91% |
| Canis familiaris | Dog | XP_547689.3 | 514 | 82% | 91% |
| Bos taurus | Cow | XP_002697813.1 | 514 | 81% | 91% |
| Loxodonata africana | Elephant | XP_003406348.1 | 514 | 80% | 91% |
| Rattus norvegicus | Rat | XP_001053914.2 | 514 | 71% | 87% |
| Mus musculus | Mouse | NP_083224.2 | 514 | 70% | 87% |
| Ornithorhynchus anatinus | Platypus | XP_001509001.2 | 465 | 49% | 72% |
| Monodelphis domestica | Opossum | XP_001372850.2 | 507 | 47% | 70% |
| Xenopus tropicalis | Frog | NP_001120281.1 | 516 | 39% | 65% |
| Anolis carolinensis | Lizard | XP_003227331.1 | 514 | 37% | 62% |
| Nematostella vectensis | Sea anemone | XP_001628275.1 | 440 | 36% | 58% |
| Branchiostoma floridae | Lancelet | XP_002609924.1 | 528 | 35% | 61% |
| Trichoplax adhaerens | Trichoplax | XP_002111027.1 | 514 | 33% | 60% |
| Danio rerio | Zebra fish | NP_001038595.2 | 519 | 32% | 58% |
| Amphimedon queenslandica | Sponge | XP_003389146.1 | 513 | 31% | 60% |
Gene neighborhood
The below image from NCBI shows the gene neighborhood of CCDC11 on chromosome 18. CCDC11 has methyl-CPG binding domain protein 1, MBD1, upstream and myosin VB3, MYO5B, downstream. All CCDC11, MBD1 and MYO5B are oriented negatively. Note the close proximity between MBD1 and CCDC11.
Predicted Post-Translational Modification
Tools on the ExPASy Proteomics site[3] predict the following post-translational modifications:
| Tool | Predicted Modification | Homo sapiens | Mus musculus | Bos taurus |
| YinOYang[4] | O-β-GlcNAc | T239, S510 | T239 | T239, S509, T510 |
| NetPhos[5] | phosphorylation | T8, T17, S43, S53, S56, S57, Y112, T134, S170, S240, S425, S461 | T17, S43, S53, S56, S107, Y112, S114, S170, T284, S287, S492 | T17, S56, T64, S107, T112, T122, T325, S442, S482, S507 |
One tool on the ExPASy, iPSORT, showed no signal peptide;however, it indicated CCDC11 to be mitochondrial. Another tool on the ExPASy, SOSUI, indicated the protein to be a soluble protein.
References
- "coiled-coil domain containing 11". Retrieved 25 Feb 2012.
- "GeneCards". Retrieved 25 Feb 2012.
- "ExPASy Proteomics tools". Retrieved 15 Apr 2012.
- "YinOYang". Retrieved 15 Apr 2012.
- "NetPhos". Retrieved 15 Apr 2012.