C1QTNF1

Complement C1q tumor necrosis factor-related protein 1 is a protein that in humans is encoded by the C1QTNF1 gene.[5][6]

C1QTNF1
Identifiers
Aliases	C1QTNF1, CTRP1, GIP, ZSIG37, C1q and tumor necrosis factor related protein 1, C1q and TNF related 1
External IDs	OMIM: 610365 MGI: 1919254 HomoloGene: 10548 GeneCards: C1QTNF1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 79,022,814 bp[1] End 79,049,788 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 118,428,203 bp[2] End 118,449,963 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • collagen binding Cellular component • extracellular region • collagen • integral component of plasma membrane • extracellular Biological process • positive regulation of cytosolic calcium ion concentration • negative regulation of platelet activation • protein heterotrimerization • regulation of glucose metabolic process • positive regulation of gene expression • positive regulation of protein kinase B signaling • positive regulation of aldosterone secretion • protein homooligomerization • negative regulation of platelet aggregation • positive regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114897	56745
Ensembl	ENSG00000173918	ENSMUSG00000017446
UniProt	Q9BXJ1	Q9QXP7
RefSeq (mRNA)	NM_030968 NM_153372 NM_198593 NM_198594	NM_001204129 NM_001204130 NM_019959
RefSeq (protein)	NP_112230 NP_699203 NP_940995 NP_940996	NP_001191058 NP_001191059 NP_064343
Location (UCSC)	Chr 17: 79.02 – 79.05 Mb	Chr 11: 118.43 – 118.45 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

C1QTNF1 has been shown to interact with Arginine vasopressin receptor 2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000173918 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017446 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.
6. "Entrez Gene: C1QTNF1 C1q and tumor necrosis factor related protein 1".
7. Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.

External links

• Human C1QTNF1 genome location and C1QTNF1 gene details page in the UCSC Genome Browser.
• Human GIP genome location and GIP gene details page in the UCSC Genome Browser.

Further reading

• Innamorati G, Bianchi E, Whang MI (June 2006). "An intracellular role for the C1q-globular domain". Cellular Signalling. 18 (6): 761–70. doi:10.1016/j.cellsig.2005.11.004. PMID 16386877.
• Kim KY, Kim HY, Kim JH, Lee CH, Kim DH, Lee YH, Han SH, Lim JS, Cho DH, Lee MS, Yoon S, Kim KI, Yoon DY, Yang Y (July 2006). "Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue". FEBS Letters. 580 (16): 3953–60. doi:10.1016/j.febslet.2006.06.034. PMID 16806199. S2CID 84691242.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.