Brooke Greenberg

Brooke Megan Greenberg (January 8, 1993 – October 24, 2013)[1][2] was an American woman who remained physically and cognitively similar to a toddler, despite her increasing age. She was about 30 in (76 cm) tall, weighed about 16 lb (7.3 kg) and had an estimated mental age of nine months to one year. Brooke's doctors termed her condition Syndrome X.

Brooke Greenberg
Born
Brooke Megan Greenberg

(1993-01-08)January 8, 1993
Baltimore, Maryland, United States
DiedOctober 24, 2013(2013-10-24) (aged 20)
Baltimore, Maryland, United States
Cause of deathBronchomalacia
Known forSyndrome X Disease

Birth and early life

Brooke was born on January 8, 1993[1][3] to parents Howard and Melanie Greenberg[4] at Sinai Hospital in Baltimore, Maryland. She was delivered by Caesarean section, one month before her due date due to "intermittent growth",[5] weighing just four pounds (1.8 kg). She was born with anterior hip dislocation, a condition that caused her legs to be swiveled upward toward her shoulders; it was corrected surgically. Otherwise, Brooke appeared to be a normal infant.[6] She was the third of four girls born to her parents.[5]

In her first six years, she went through a series of unexplained medical emergencies from which she recovered. She had seven perforated stomach ulcers. She also suffered a seizure. This was followed by what was later diagnosed as a stroke; weeks later, no damage was detected. At age five, Brooke had a mass in her brain that caused her to go into a deep sleep (after confirmation that it was not a coma) for 14 days. The doctors diagnosed the mass as a brain tumor. She later awoke, and physicians found no tumor present. Brooke's pediatrician, Dr. Lawrence Pakula, states that the source of her sudden illness remains a mystery.[7]

During an interview on the talk show Katie, her father stated that between the ages of four and five, she stopped growing.[8] Child Frozen In Time, a documentary about Brooke,[5] was first broadcast on TLC on August 9, 2009.[9]

Unexplained condition

Over several years, the Greenbergs visited many specialists, looking for an explanation for their daughter's strange condition, yet there was no diagnosis of any known genetic syndrome or chromosomal abnormality.[10] In 2001, when Dateline documented Brooke at eight years of age, she was still the size of a six-month-old infant, weighing just 13 lb (5.9 kg) at 30 inches (76 cm) tall. The family still had no explanation. Brooke's mother Melanie said, "They [the specialists] just said she’ll catch up. Then we went to the nutritionist, the endocrinologist. We tried the growth hormone…". The growth hormone treatment had no effect. Howard, Brooke's father, said, "I mean, she did not put on an ounce, or she did not grow an inch... That’s when I knew there was a problem." After the growth hormone administration failed, the doctors, unable to diagnose a known condition, named her condition Syndrome X.

The Greenbergs made many visits to nearby Johns Hopkins Children's Center and even took Brooke to New York’s Mount Sinai Hospital, searching for information about their daughter’s condition.[6] When geneticists sequenced Greenberg's DNA, they found that the genes associated with the premature aging diseases were normal, unlike the mutated versions in patients with Werner syndrome and progeria.[11]

Medical studies

In 2006, Richard Walker, an endocrine physiologist at the University of South Florida College of Medicine, said that Brooke's body was not developing as a coordinated unit but as independent parts that were out of synchronization.[12][13][14] She was never diagnosed with any known genetic disorder or chromosomal abnormality that would help explain why.[7] Her telomeres seemed to be shortening at the normal rate.[10]

In 2009, Walker said, "There've been very minimal changes in Brooke's brain … Various parts of her body, rather than all being at the same stage, seem to be disconnected."[7] Walker noted that Brooke's brain, for example, was not much more mature than that of a newborn infant. He estimated her mental age at around nine months to a year old. Brooke could make gestures and recognize sounds but could not speak. Her bones were like those of a ten-year-old, and she still had her baby teeth, which had an estimated developmental age of about eight years. Said Walker, "We think that Brooke's condition presents us with a unique opportunity to understand the process of aging."[15] "Different parts of her body are developing at different rates, as if they were not a unit but parts of separate organisms," Walker explained.[1] Dr. Walker did not say whether the genes responsible for development are the same ones responsible for aging.

Death

Brooke Greenberg died on October 24, 2013, at the Herman and Walter Samuelson Children's Hospital at Sinai Medical Center in Baltimore, the same hospital where she was born. Her funeral service took place on October 27, 2013, and that same morning, she was buried at Baltimore Hebrew Cemetery - Berrymans Lane, in Reisterstown, Maryland.[2] The cause of her death was bronchomalacia, a medical condition usually occurring in children, which results in difficulty breathing due to weak cartilage in the walls of the bronchial tubes.[16]

Comparable cases

Dr. Walker believed that Brooke Greenberg's condition had resulted from a failure of central control genes. He identified two more people with similar developmental issues: Gabrielle Williams[17] of Montana (born in 2004) and Nicky Freeman[18] of Australia (born on December 28, 1969), a middle aged man who looks like a preteen boy.

Gabrielle Williams's condition has since been determined to have been the result of a genetic mutation. Nicky Freeman has been diagnosed with deformity of the pituitary gland.

María Audenete do Nascimento, a Brazilian woman who lives in the town of Caucaia near Fortaleza in the state of Ceará, Brazil, was once thought to have also been suffering from a condition similar to Greenberg's. She was reportedly born in May 1981 but stopped growing after nine months.[19] She has been diagnosed with severe hypothyroidism.

In May 2015, it was reported that Layla Qualls of Oklahoma looks as if she is 9 or 10 months old, but is 3 years old. She was among seven children worldwide with Syndrome X that are being studied by researchers at the University of California, Los Angeles. She passed away on January 7 2020 at the age of 7. In their ongoing research they found that the blood of Syndrome X children appears to age normally.[20] Layla has also been featured in a TLC documentary titled "The Girls Who Don't Age". This documentary aired July 18, 2016 on TLC.[21]

In July 2016, it was reported that Alyssa Pennington of New Mexico looks like she is five years old, but is 12 years old.[21] She is another Syndrome X case.[22]

Another case that has been reported in July 2016 is Jenifer Sandoval of Colorado. Although she looks like she is four years old, she is 22 years old.[21][23]

In April 2017, NTD Television reported about Manpreet Singh from a village in the northern Mansa, India. At 22 years old, he is only 23 inches (58 cm) tall and was born after ten months. He did not show any signs of growth and development such as speaking after six months. Doctors said his condition could be caused by his late birth and a deficiency of growth hormones.[24]

Another reported case in 2017 is Angus Palmes from Macclesfield, UK. At the age of 13 he weighs 2.14 stone (30.0 lb) and has a height of 3 feet 1 inch (94 cm). He is believed to have a chromosomal translocation of 15/20 and a partial trisomy of 22q12.3.[25]

Blood tissue from five other female Syndrome X cases (whose average age was 6.3 years) turned out to be age-appropriate[26] according to a biomarker of aging known as epigenetic clock. The mean epigenetic age of the five pure Syndrome X subjects was 6.7 years (standard error=1.0) which is not significantly different from the mean chronological age of 6.3 years (standard error=1.8). Notably, the oldest pure Syndrome X case had an epigenetic age of 14.5 years which was 3.2 years older than her true chronological age. It is not yet known whether the epigenetic age of other tissues is also age appropriate in these cases.

Neotenic complex syndrome
Main article: Neotenic complex syndrome

Blood samples from each of the "Syndrome X" girls were sent to Dr. Radoje Drmanac in San Francisco, who did a full genomic sequencing and found the common link shared by the girls, leading the syndrome to be renamed "neotenic complex syndrome".[27][28]

References
  1. Bethge, Philip (October 29, 2010). "Brooke the Immortal: An American Child May Hold Secrets to Aging". Der Spiegel. Retrieved May 30, 2014.
  2. Brooke Megan Greenberg, obituary and condolences at the Sol Levinson & Bros., Inc. site, stored at the Wayback Machine
  3. "The Curious Case of Brooke Greenberg: 16-Year-Old Has the Body and Mind of a Toddler". Fox News. August 7, 2009. Retrieved May 30, 2014.
  4. Frozen in Time. Fox & Friends (TV news program). republished online on May 3, 2011. August 2009. Retrieved January 20, 2016.
  5. Girl Frozen In Time. uploaded to YouTube (TV Documentary). TLC. August 9, 2009. Retrieved January 20, 2016.
  6. James, Sara (October 23, 2005). "A child frozen in time". NBC News.
  7. Brown, Bob (June 23, 2006). "Doctors Baffled, Intrigued by Girl Who Doesn't Age". Health. ABC News. Retrieved June 27, 2009.
  8. Greenfield, Beth (January 11, 2013). "'Toddler' is 20 Years Old, and Forever Young, Due to Baffling Medical Condition". Yahoo.com. Retrieved January 12, 2013.
  9. "Brooke Greenberg". Mahalo.com. Retrieved January 20, 2009.
  10. Walker, R.; Pakula, L.; Sutcliffe, M.; Kruk, P.; Graakjaer, J.; Shay, J. (2009). "A case study of "disorganized development" and its possible relevance to genetic determinants of aging". Mechanisms of Ageing and Development. 130 (5): 350–356. doi:10.1016/j.mad.2009.02.003. PMID 19428454. S2CID 11036362.
  11. Coghlan, Andy (June 25, 2009). "Teenage 'baby' may lack master ageing gene". New Scientist.
  12. "Clinical Interventions in Aging". Dove Medical Press Ltd. 2009. Retrieved July 25, 2010.
  13. "20-Year-Old Dies Never Having Aged". ABC News. October 29, 2013. Retrieved April 10, 2018.
  14. "Forever Young: Benjamin Button Children Never Grow or Age". ABC News. January 21, 2011. Retrieved April 10, 2018.
  15. Hall, Christi (May 10, 2010). "Brooke Greenberg Frozen in Time - 17-Year Old 'Toddler'". National Ledger. Retrieved May 12, 2010.
  16. Davis, Nayana (October 30, 2013). "Brooke Greenberg, 20, who suffered from rare genetic condition, dies". The Baltimore Sun.
  17. Healy, Donna (May 22, 2011). "Medical Mystery: Tiny Billings girl thrives on her family's love". Billings Gazette. Retrieved January 29, 2012.
  18. Calautti, Lisa (February 27, 2010). "Forty-year-old trapped in child's body". The West Australian. Retrieved January 29, 2012.
  19. "Presa no Corpo de Uma Criança". 31 May 2013. Discovery Brasil's YouTube channel. Retrieved August 31, 2013.
  20. "Oklahoma girl's rare syndrome prevents her from aging". Fox News. May 8, 2015. Retrieved May 9, 2015.
  21. Girls Who Don't Age. uploaded to YouTube (TV Documentary). TLC. July 20, 2016. Retrieved July 20, 2016.
  22. "New Mexico girl one of six with rare genetic disorder". KRQE News 13. July 19, 2016. Retrieved July 20, 2016.
  23. "The Real Peter Pans: The Girls Who Don't Age". Barcroft Media Ltd. July 16, 2016. Retrieved July 16, 2016.
  24. "Mysterious illness leaves Indian man trapped in toddler's body". NTD Television. April 14, 2017. Archived from the original on April 24, 2017. Retrieved April 24, 2017.
  25. Adams, Chris; Greer, Stuart (August 15, 2017). "Meet Angus - the brave 13-year-old boy with a rare condition that means he's the size of a toddler". men. Retrieved February 2, 2019.
  26. Walker, R. F.; Liu, J. S.; Peters, B. A.; Ritz, B. R.; Wu, T; Ophoff, R. A.; Horvath, S (2015). "Epigenetic age analysis of children who seem to evade aging". Aging. 7 (5): 334–9. doi:10.18632/aging.100744. PMC 4468314. PMID 25991677.
  27. "The real Peter Pans: The Girls Who Don't Age". Barcroft TV.
  28. Walker, Richard F; Ciotlos, Serban; Mao, Qing; Chin, Robert; Drmanac, Snezana; Barua, Nina; Agarwal, Misha R; Zhang, Rebecca Yu; Li, Zhenyu; Wu, Michelle Ka Yan; Sun, Kevin; Lee, Katharine; Nguyen, Staci; Liu, Jia Sophie; Carnevali, Paolo; Drmanac, Radoje; Peters, Brock A (2018). "Clinical and genetic analysis of a rare syndrome associated with neoteny". Genetics in Medicine. 19 (9): 495–502. doi:10.1038/gim.2017.140. PMID 29758565.
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