Bromoxynil nitrilase
In enzymology, a bromoxynil nitrilase (EC 3.5.5.6) is an enzyme that catalyzes the chemical reaction
- 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O 3,5-dibromo-4-hydroxy-benzoate + NH3
bromoxynil nitrilase | |||||||||
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Identifiers | |||||||||
EC number | 3.5.5.6 | ||||||||
CAS number | 157857-12-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are 3,5-dibromo-4-hydroxybenzonitrile and H2O, whereas its two products are 3,5-dibromo-4-hydroxy-benzoate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is 3,5-dibromo-4-hydroxybenzonitrile aminohydrolase. This enzyme participates in 1,4-dichlorobenzene degradation.
References
- Stalker DM, Malyj LD, McBride KE (1988). "Purification and properties of a nitrilase specific for the herbicide bromoxynil and corresponding nucleotide sequence analysis of the bxn gene". J. Biol. Chem. 263 (13): 6310–4. PMID 2834373.
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