Biotin carboxyl carrier protein

Biotin Carboxyl Carrier Protein (BCCP) refers to proteins containing a biotin attachment domain that carry biotin and carboxybiotin throughout the ATP-dependent carboxylation by biotin-dependent carboxylases. In the case of E. coli Acetyl-CoA carboxylase, the BCCP is a separate protein known as accB (P0ABD8). On the other hand, in Haloferax mediterranei Propionyl-CoA carboxylase, the BCCP pccA (I3R7G3) is fused with biotin carboxylase.