BTG3

Protein BTG3 is a protein that in humans is encoded by the BTG3 gene.[5][6]

BTG3
Identifiers
Aliases	BTG3, ANA, TOB5, TOB55, TOFA, BTG family member 3, BTG anti-proliferation factor 3, ANA/APRO4
External IDs	OMIM: 605674 MGI: 109532 HomoloGene: 4953 GeneCards: BTG3
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.1 Start 17,593,653 bp[1] End 17,612,947 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.1 Start 78,332,637 bp[2] End 78,377,192 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cell nucleus Biological process • negative regulation of cell proliferation • negative regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10950	12228
Ensembl	ENSG00000281484 ENSG00000154640	ENSMUSG00000022863
UniProt	Q14201 Q6IAU3	P50615
RefSeq (mRNA)	NM_001130914 NM_006806	NM_001297747 NM_009770
RefSeq (protein)	NP_001124386 NP_006797 NP_001124386.1 NP_006797.3	NP_001284676 NP_033900
Location (UCSC)	Chr 21: 17.59 – 17.61 Mb	Chr 16: 78.33 – 78.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system.[6]

References

1. ENSG00000154640 GRCh38: Ensembl release 89: ENSG00000281484, ENSG00000154640 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022863 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T (Jun 1998). "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system". Oncogene. 16 (20): 2687–93. doi:10.1038/sj.onc.1201805. PMID 9632145. S2CID 10053424.
6. "Entrez Gene: BTG3 BTG family, member 3".

External links

• Human BTG3 genome location and BTG3 gene details page in the UCSC Genome Browser.

Further reading

• Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family". FEBS Lett. 497 (2–3): 67–72. doi:10.1016/S0014-5793(01)02436-X. PMID 11377414. S2CID 43120613.
• Guéhenneux F, Duret L, Callanan MB, et al. (1997). "Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle". Leukemia. 11 (3): 370–5. doi:10.1038/sj.leu.2400599. PMID 9067576.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Birot A, Duret L, Bartholin L, et al. (2000). "Identification and molecular analysis of BANP". Gene. 253 (2): 189–96. doi:10.1016/S0378-1119(00)00244-4. PMID 10940556.
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753. PMID 11429045.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Ou YH, Chung PH, Hsu FF, et al. (2007). "The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1". EMBO J. 26 (17): 3968–80. doi:10.1038/sj.emboj.7601825. PMC 1994125. PMID 17690688.