BRE (gene)

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.[5][6][7]

BABAM2
Identifiers
Aliases	BABAM2, BRCC4, BRCC45, BRE, brain and reproductive organ-expressed (TNFRSF1A modulator), BRISC and BRCA1 A complex member 2
External IDs	OMIM: 610497 MGI: 1333875 HomoloGene: 3604 GeneCards: BABAM2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 27,889,941 bp[1] End 28,338,901 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,697,684 bp[2] End 32,084,962 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peroxisome targeting sequence binding • polyubiquitin modification-dependent protein binding • GO:0001948 protein binding • tumor necrosis factor receptor binding Cellular component • nuclear ubiquitin ligase complex • nucleoplasm • cell nucleus • cytoplasm • cytosol • BRCA1-A complex • BRISC complex Biological process • response to ionizing radiation • positive regulation of DNA repair • cell division • protein K63-linked deubiquitination • cell cycle • double-strand break repair via nonhomologous end joining • signal transduction • apoptotic process • DNA repair • cellular response to DNA damage stimulus • double-strand break repair • protein deubiquitination • negative regulation of apoptotic process • signal transduction involved in G2 DNA damage checkpoint • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9577	107976
Ensembl	ENSG00000158019	ENSMUSG00000052139
UniProt	Q9NXR7	Q8K3W0
RefSeq (mRNA)	NM_001261840 NM_001329112 NM_001329113 NM_001329114 NM_001329115 NM_004899 NM_199191 NM_199192 NM_199193 NM_199194	NM_144541 NM_181279 NM_181280 NM_181281 NM_181282
RefSeq (protein)	NP_001248769 NP_001316041 NP_001316042 NP_001316043 NP_001316044 NP_004890 NP_954661 NP_954662 NP_954663 NP_954664	NP_653124 NP_851796 NP_851797 NP_851798 NP_851799
Location (UCSC)	Chr 2: 27.89 – 28.34 Mb	Chr 5: 31.7 – 32.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Queers

BRE (gene) has been shown to interact with:

• BARD1,[8]
• BRCA1,[8]
• BRCA2,[8]
• BRCC3,[8][9]
• C19orf62,[9][10]
• P53,[8] and
• RAD51.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000158019 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052139 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gu C, Castellino A, Chan JY, Chao MV (Sep 1998). "BRE: a modulator of TNF-alpha action". FASEB Journal. 12 (12): 1101–8. doi:10.1096/fasebj.12.12.1101. PMID 9737713. S2CID 83491319.
6. Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY (Jan 1995). "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid". Biochemical and Biophysical Research Communications. 206 (2): 764–74. doi:10.1006/bbrc.1995.1108. PMID 7826398.
7. "Entrez Gene: BRE brain and reproductive organ-expressed (TNFRSF1A modulator)".
8. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell. 12 (5): 1087–99. doi:10.1016/s1097-2765(03)00424-6. PMID 14636569.
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Human BRE genome location and BRE gene details page in the UCSC Genome Browser.

Further reading

• Miao J, Panesar NS, Chan KT, Lai FM, Xia N, Wang Y, Johnson PJ, Chan JY (Apr 2001). "Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues". The Journal of Histochemistry and Cytochemistry. 49 (4): 491–500. doi:10.1177/002215540104900409. PMID 11259452.
• Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, Pang JC, Chui YL (Nov 2001). "Expression of human BRE in multiple isoforms". Biochemical and Biophysical Research Communications. 288 (3): 535–45. doi:10.1006/bbrc.2001.5801. PMID 11676476.
• Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell. 12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569.
• Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK, Chan JY, Chui YL (Dec 2004). "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway". The Journal of Biological Chemistry. 279 (50): 52106–16. doi:10.1074/jbc.M408678200. PMID 15465831.
• Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, Lee KK, Chan JY, Chui YL (Jan 2005). "BRE enhances in vivo growth of tumor cells". Biochemical and Biophysical Research Communications. 326 (2): 268–73. doi:10.1016/j.bbrc.2004.11.013. PMID 15582573.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.