BRD7

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.[5][6][7]

BRD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I7K
Identifiers
Aliases	BRD7, BP75, CELTIX1, NAG4, bromodomain containing 7
External IDs	OMIM: 618489 MGI: 1349766 HomoloGene: 8085 GeneCards: BRD7
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q12.1 Start 50,313,487 bp[1] End 50,368,934 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 88,331,039 bp[2] End 88,362,194 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • histone binding • p53 binding • transcription factor binding • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • lysine-acetylated histone binding Cellular component • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • negative regulation of G1/S transition of mitotic cell cycle • cell cycle • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • Wnt signaling pathway • transcription, DNA-templated • negative regulation of cell proliferation • positive regulation of histone acetylation • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29117	26992
Ensembl	ENSG00000166164	ENSMUSG00000031660
UniProt	Q9NPI1	O88665
RefSeq (mRNA)	NM_001173984 NM_013263	NM_012047
RefSeq (protein)	NP_001167455 NP_037395	NP_036177 NP_001363942 NP_001363943 NP_001363944 NP_001363945 NP_001363946
Location (UCSC)	Chr 16: 50.31 – 50.37 Mb	Chr 8: 88.33 – 88.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

BRD7 has been shown to interact with IRF2[8] and HNRPUL1.[9]

Azoospermia

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.[10] Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000166164 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031660 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W (November 1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett. 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6. PMID 10526152. S2CID 41216030.
6. Kaeser MD, Aslanian A, Dong MQ, Yates JR III, Emerson BM (November 2008). "BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells". J Biol Chem. 283 (47): 32254–32263. doi:10.1074/jbc.M806061200. PMC 2583284. PMID 18809673.
7. "Entrez Gene: BRD7 bromodomain containing 7".
8. Staal, A; Enserink J M; Stein J L; Stein G S; van Wijnen A J (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. UNITED STATES. 185 (2): 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. ISSN 0021-9541. PMID 11025449.
9. Kzhyshkowska, Julia; Rusch Andre; Wolf Hans; Dobner Thomas (April 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. England. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. ISSN 0264-6021. PMC 1223277. PMID 12489984.
10. Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M (2016). "Knockout of BRD7 results in impaired spermatogenesis and male infertility". Sci Rep. 6: 21776. Bibcode:2016NatSR...621776W. doi:10.1038/srep21776. PMC 4754950. PMID 26878912.

External links

• Human BRD7 genome location and BRD7 gene details page in the UCSC Genome Browser.

Further reading

• Staal A, Enserink JM, Stein JL, et al. (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kzhyshkowska J, Rusch A, Wolf H, Dobner T (2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMC 1223277. PMID 12489984.
• Zhou M, Peng C, Nie XM, et al. (2003). "[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]". AI Zheng. 22 (2): 123–7. PMID 12600283.
• Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–2596. doi:10.1167/iovs.02-1099. PMID 12766061.
• Zhang XM, Wang XY, Sheng SR, et al. (2003). "Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer". World J. Gastroenterol. 9 (8): 1729–33. doi:10.3748/wjg.v9.i8.1729. PMC 4611532. PMID 12918109.
• Kim S, Lee J, Park J, Chung J (2003). "BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta". Cancer Res. 63 (16): 4792–5. PMID 12941796.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Zhou J, Ma J, Zhang BC, et al. (2004). "BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways". J. Cell. Physiol. 200 (1): 89–98. doi:10.1002/jcp.20013. PMID 15137061. S2CID 10383569.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Peng C, Zhou J, Liu HY, et al. (2006). "The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain". J. Cell. Biochem. 97 (4): 882–892. doi:10.1002/jcb.20645. PMID 16265664. S2CID 25852399.
• Zhou M, Liu H, Xu X, et al. (2006). "Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression". J. Cell. Biochem. 98 (4): 920–930. doi:10.1002/jcb.20788. PMID 16475162. S2CID 23757847.
• Zhou M, Xu XJ, Zhou HD, et al. (2007). "BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis". Mol. Cell. Biochem. 292 (1–2): 205–212. doi:10.1007/s11010-006-9233-4. PMID 16786191. S2CID 5979230.
• Liu H, Peng C, Zhou M, et al. (2006). "Cloning and characterization of the BRD7 gene promoter". DNA Cell Biol. 25 (6): 346–358. doi:10.1089/dna.2006.25.346. PMID 16792505.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.