BPIFB1

BPI fold containing family B, member 1 is a protein that in humans is encoded by the BPIFB1 gene.[5]

BPIFB1
Identifiers
AliasesBPIFB1, C20orf114, LPLUNC1, BPI fold containing family B member 1
External IDsMGI: 2137431 HomoloGene: 50047 GeneCards: BPIFB1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.21Start33,273,480 bp[1]
End33,309,871 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

92747

228801

Ensembl

ENSG00000125999

ENSMUSG00000027485

UniProt

Q8TDL5

Q61114

RefSeq (mRNA)

NM_033197

NM_001012392
NM_153418

RefSeq (protein)

NP_149974

NP_001012392
NP_700467

Location (UCSC)Chr 20: 33.27 – 33.31 MbChr 2: 154.19 – 154.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008].

Model organisms

Model organisms have been used in the study of BPIFB1 function. A conditional knockout mouse line called Bpifb1tm1e(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12] - in-depth bone and cartilage phenotyping[13]

References

  1. GRCh38: Ensembl release 89: ENSG00000125999 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027485 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: BPI fold containing family B, member 1".
  6. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  7. "International Mouse Phenotyping Consortium".
  8. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  11. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  12. "Infection and Immunity Immunophenotyping (3i) Consortium".
  13. "OBCD Consortium".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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