BCL9L

B-cell CLL/lymphoma 9 like is a protein that in humans is encoded by the BCL9L gene. [5]

BCL9L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XB1, 4UP0, 4UP5
Identifiers
Aliases	BCL9L, BCL9-2, DLNB11, B-cell CLL/lymphoma 9-like, B-cell CLL/lymphoma 9 like, B cell CLL/lymphoma 9 like, B9L, BCL9 like
External IDs	OMIM: 609004 MGI: 1933114 HomoloGene: 65615 GeneCards: BCL9L
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,893,875 bp[1] End 118,925,608 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 44,482,825 bp[2] End 44,511,896 bp[2]
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • beta-catenin binding Cellular component • nucleolus • cell nucleus • nucleoplasm • beta-catenin-TCF complex Biological process • regulation of cell morphogenesis • regulation of transcription, DNA-templated • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of epithelial to mesenchymal transition • transcription, DNA-templated • beta-catenin-TCF complex assembly • canonical Wnt signaling pathway • somatic stem cell population maintenance • skeletal muscle cell differentiation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	283149	80288
Ensembl	ENSG00000186174	ENSMUSG00000063382
UniProt	Q86UU0	Q67FY2
RefSeq (mRNA)	NM_182557 NM_001378213 NM_001378214	NM_030256 NM_001357490
RefSeq (protein)	NP_872363 NP_001365142 NP_001365143	NP_084532 NP_001344419
Location (UCSC)	Chr 11: 118.89 – 118.93 Mb	Chr 9: 44.48 – 44.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000186174 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063382 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: B-cell CLL/lymphoma 9 like". Retrieved 2017-10-31.

Further reading

• Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". Mol. Cell. 24 (2): 293–300. doi:10.1016/j.molcel.2006.09.001. PMID 17052462.
• Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M (2010). "Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor". J. Mol. Biol. 401 (5): 969–84. doi:10.1016/j.jmb.2010.07.007. PMC 2927781. PMID 20637214.
• Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W (2011). "BCL9-2 promotes early stages of intestinal tumor progression". Gastroenterology. 141 (4): 1359–70, 1370.e1–3. doi:10.1053/j.gastro.2011.06.039. PMID 21703997.
• Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T (2011). "Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway". Nat Commun. 2: 548. doi:10.1038/ncomms1551. PMID 22109522.
• Zatula N, Wiese M, Bunzendahl J, Birchmeier W, Perske C, Bleckmann A, Brembeck FH (2014). "The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis". Oncotarget. 5 (16): 6770–87. doi:10.18632/oncotarget.2252. PMC 4196162. PMID 25149534.
• El-Hage P, Petitalot A, Monsoro-Burq AH, Maczkowiak F, Driouch K, Formstecher E, Camonis J, Sabbah M, Bièche I, Lidereau R, Lallemand F (2015). "The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells". Mol. Cancer Res. 13 (5): 902–12. doi:10.1158/1541-7786.MCR-14-0180. PMID 25678599.