B3GALT4

Beta-1,3-galactosyltransferase 4 is an enzyme that in humans is encoded by the B3GALT4 gene.[5][6]

B3GALT4
Identifiers
AliasesB3GALT4, BETA3GALT4, GALT2, GALT4, beta-1,3-galactosyltransferase 4
External IDsOMIM: 603095 MGI: 1859517 HomoloGene: 2805 GeneCards: B3GALT4
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.32Start33,277,123 bp[1]
End33,284,832 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8705

54218

Ensembl

ENSMUSG00000067370

UniProt

O96024

Q9Z0F0

RefSeq (mRNA)

NM_003782

NM_019420

RefSeq (protein)

NP_003773

NP_062293

Location (UCSC)Chr 6: 33.28 – 33.28 MbChr 17: 33.95 – 33.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis.[6]

References

Further reading


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