Arylamine N-acetyltransferase
In enzymology, an arylamine N-acetyltransferase (EC 2.3.1.5) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + an arylamine CoA + an N-acetylarylamine
| arylamine N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.5 | ||||||||
| CAS number | 9027-33-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetyl-CoA and arylamine, whereas its two products are CoA and N-acetylarylamine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GX3, 1W5R, 1W6F, 2BSZ, 2IJA, 2PFR, and 2PQT.
References
- CHOU TC, LIPMANN F (1952). "Separation of acetyl transfer enzymes in pigeon liver extract". J. Biol. Chem. 196 (1): 89–103. PMID 12980945.
- Paul RC, Ratledge C (1973). "Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes". Biochim. Biophys. Acta. 320 (1): 9–15. doi:10.1016/0304-4165(73)90160-8. PMID 4748369.
- Tabor H, Mehler AH, Stadtman ER (1953). "The enzymatic acetylation of amines". J. Biol. Chem. 204 (1): 127–138. PMID 13084583.
- Weissbach H, Redfield BG, Axelrod J (1961). "The enzymic acetylation of serotonin and other naturally occurring amines". Biochim. Biophys. Acta. 54 (1): 190–192. doi:10.1016/0006-3002(61)90954-4. PMID 14005907.