Arsenite-transporting ATPase
In enzymology, an arsenite-transporting ATPase (EC 3.6.3.16) is an enzyme that catalyzes the chemical reaction
- ATP + H2O + arsenitein ADP + phosphate + arseniteout
| arsenite transmembrane-transporting ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.3.16 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are ATP, H2O, and arsenite, whereas its 3 products are ADP, phosphate, and arsenite.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting).
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1IHU, 1II0, and 1II9.
See also
References
- Silver S, Misra TK, Laddaga RA (1989). "DNA sequence analysis of bacterial toxic heavy metal resistances". Biol. Trace Elem. Res. 21: 145–63. doi:10.1007/BF02917247. PMID 2484581. S2CID 19834681.
- Rosen BP, Weigel U, Monticello RA, Edwards BP (1991). "Molecular analysis of an anion pump: purification of the ArsC protein". Arch. Biochem. Biophys. 284 (2): 381–5. doi:10.1016/0003-9861(91)90312-7. PMID 1703401.
- Rosen BP, Weigel U, Monticello RA, Edwards BP (1991). "Molecular analysis of an anion pump: purification of the ArsC protein". Arch. Biochem. Biophys. 284 (2): 381–5. doi:10.1016/0003-9861(91)90312-7. PMID 1703401.
- Zhou T, Rosen BP, Gatti DL (1999). "Crystallization and preliminary x-ray analysis of the catalytic subunit of the ATP-dependent arsenite pump encoded by the Escherichia coli plasmid R773". Acta Crystallogr. D. 55 (Pt 4): 921–4. doi:10.1107/S0907444999000256. PMID 10089335.
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