Annexin A13

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.[4][5]

ANXA13
Identifiers
Aliases	ANXA13, ANX13, ISA, annexin A13
External IDs	OMIM: 602573 MGI: 1917037 HomoloGene: 20908 GeneCards: ANXA13
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.13 Start 123,680,794 bp[1] End 123,737,402 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium-dependent phospholipid binding • calcium ion binding • phosphatidylserine binding • phosphatidylcholine binding • phosphatidylglycerol binding Cellular component • membrane raft • cell membrane • basolateral plasma membrane • extracellular exosome • apical plasma membrane • exocytic vesicle • membrane • nucleoplasm • extracellular Biological process • positive regulation of Golgi to plasma membrane protein transport • cell differentiation • negative regulation of Golgi to plasma membrane protein transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	312	69787
Ensembl	ENSG00000104537	ENSMUSG00000055114
UniProt	P27216	Q99JG3
RefSeq (mRNA)	NM_004306 NM_001003954	NM_027211
RefSeq (protein)	NP_001003954 NP_004297	NP_081487
Location (UCSC)	Chr 8: 123.68 – 123.74 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membranes of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000104537 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1998). "Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins". Genomics. 48 (1): 100–10. doi:10.1006/geno.1997.5148. PMID 9503022.
5. "Entrez Gene: ANXA13 annexin A13".

External links

• Human ANXA13 genome location and ANXA13 gene details page in the UCSC Genome Browser.

Further reading

• Wice BM, Gordon JI (Jan 1992). "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin". The Journal of Cell Biology. 116 (2): 405–22. doi:10.1083/jcb.116.2.405. PMC 2289284. PMID 1530946.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Plant PJ, Lafont F, Lecat S, Verkade P, Simons K, Rotin D (Jun 2000). "Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb". The Journal of Cell Biology. 149 (7): 1473–84. doi:10.1083/jcb.149.7.1473. PMC 2175132. PMID 10871286.
• Noda Y, Okada Y, Saito N, Setou M, Xu Y, Zhang Z, Hirokawa N (Oct 2001). "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes". The Journal of Cell Biology. 155 (1): 77–88. doi:10.1083/jcb.200108042. PMC 2150803. PMID 11581287.
• Iglesias JM, Morgan RO, Jenkins NA, Copeland NG, Gilbert DJ, Fernandez MP (May 2002). "Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins". Molecular Biology and Evolution. 19 (5): 608–18. doi:10.1093/oxfordjournals.molbev.a004120. PMID 11961095.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.