Angiomyofibroblastoma

Angiomyofibroblastoma is an uncommon benign mesenchymal tumor. It occurs mostly in the vulvovaginal area of women, but can also be observed in men.

The gross features of AMFB are well-circumscribed. Usually, most tumors grow slowly, and patients do not feel pain. It also has low tendency for local recurrence.

Location

In women
- Female genital tract[1]
- Vulva[2]
- Posterior perivesical space[3]
In men
- Spermatic cord[4]

Pathology

Microscopical examination shows abundant thin-walled blood vessels with hypocellular and hypercellular areas.

Immunohistochemistry

Almost all tumor cells have immunoreactivity for both desmin and vimentin. It also express estrogen receptors and/or progesterone receptors, but staining for cytokeratin is negative.[5]

References

Wang, J; Sheng, W; Tu, X; Shi, D; Zhu, X; Zhang, R (2000). "Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract". Chinese Medical Journal. 113 (11): 1036–9. PMID 11776120.
Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.
Lim, K. J.; Moon, J. H.; Yoon, D. Y.; Cha, J. H.; Lee, I. J.; Min, S. J. (2008). "Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings". Korean Journal of Radiology. 9 (4): 382–5. doi:10.3348/kjr.2008.9.4.382. PMC 2627271. PMID 18682679.
Tzanakis, N. E.; Giannopoulos, G. A.; Efstathiou, S. P.; Rallis, G. E.; Nikiteas, N. I. (2010). "Angiomyofibroblastoma of the spermatic cord: A case report". Journal of Medical Case Reports. 4: 79. doi:10.1186/1752-1947-4-79. PMC 2838917. PMID 20202207.
Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.

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[1] Wang, J; Sheng, W; Tu, X; Shi, D; Zhu, X; Zhang, R (2000). "Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract". Chinese Medical Journal. 113 (11): 1036–9. PMID 11776120.

[2] Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.

[3] Lim, K. J.; Moon, J. H.; Yoon, D. Y.; Cha, J. H.; Lee, I. J.; Min, S. J. (2008). "Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings". Korean Journal of Radiology. 9 (4): 382–5. doi:10.3348/kjr.2008.9.4.382. PMC 2627271. PMID 18682679.

[4] Tzanakis, N. E.; Giannopoulos, G. A.; Efstathiou, S. P.; Rallis, G. E.; Nikiteas, N. I. (2010). "Angiomyofibroblastoma of the spermatic cord: A case report". Journal of Medical Case Reports. 4: 79. doi:10.1186/1752-1947-4-79. PMC 2838917. PMID 20202207.

[5] Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.