Alkb homolog 1, histone h2a dioxygenase

AlkB homolog 1, histone H2A dioxygenase is a protein that in humans is encoded by the ALKBH1 gene. [4]

ALKBH1
Identifiers
Aliases	ALKBH1, ABH, ABH1, ALKBH, alkB, hABH, alkB homolog 1, histone H2A dioxygenase
External IDs	OMIM: 605345 MGI: 2384034 HomoloGene: 4393 GeneCards: ALKBH1
EC number	4.2.99.18
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 77,672,404 bp[1] End 77,708,023 bp[1]
Gene ontology Molecular function • methylcytosine dioxygenase activity • dioxygenase activity • metal ion binding • catalytic activity • lyase activity • chemoattractant activity • oxidoreductase activity • ferrous iron binding • 1-ethyladenine demethylase activity • tRNA binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • DNA-N1-methyladenine dioxygenase activity • tRNA demethylase activity • class I DNA-(apurinic or apyrimidinic site) lyase activity • DNA-(apurinic or apyrimidinic site) lyase activity Cellular component • mitochondrion • cell nucleus • nuclear euchromatin Biological process • negative regulation of neuron apoptotic process • cell differentiation • DNA dealkylation involved in DNA repair • placentation • neuron migration • in utero embryonic development • cellular response to DNA damage stimulus • oxidative demethylation • developmental growth • regulation of gene expression • RNA repair • DNA demethylation • positive chemotaxis • metabolism • neuron projection development • oxidation-reduction process • DNA repair • regulation of translation • tRNA wobble cytosine modification • regulation of translational initiation • regulation of translational elongation • oxidative single-stranded DNA demethylation • regulation of mitochondrial translation • tRNA demethylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8846	211064
Ensembl	ENSG00000100601	ENSMUSG00000079036
UniProt	Q13686	P0CB42
RefSeq (mRNA)	NM_001039506 NM_006020	NM_001102565
RefSeq (protein)	NP_006011	NP_001096035
Location (UCSC)	Chr 14: 77.67 – 77.71 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000100601 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: AlkB homolog 1, histone H2A dioxygenase". Retrieved 2018-07-12.

Further reading

• Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE (February 2003). "Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA". Nature. 421 (6925): 859–63. doi:10.1038/nature01363. PMID 12594517.
• Westbye MP, Feyzi E, Aas PA, Vågbø CB, Talstad VA, Kavli B, Hagen L, Sundheim O, Akbari M, Liabakk NB, Slupphaug G, Otterlei M, Krokan HE (September 2008). "Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA". J. Biol. Chem. 283 (36): 25046–56. doi:10.1074/jbc.M803776200. PMC 3259822. PMID 18603530.
• Müller TA, Meek K, Hausinger RP (January 2010). "Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites". DNA Repair (Amst.). 9 (1): 58–65. doi:10.1016/j.dnarep.2009.10.011. PMC 2818486. PMID 19959401.
• Shankaracharya, Das S, Vidyarthi AS (September 2011). "Homology modeling and function prediction of hABH1, involving in repair of alkylation damaged DNA". Interdiscip Sci. 3 (3): 175–81. doi:10.1007/s12539-011-0087-4. PMID 21956739.
• Müller TA, Andrzejak MM, Hausinger RP (June 2013). "A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1)". Biochem. J. 452 (3): 509–18. doi:10.1042/BJ20121908. PMC 4126167. PMID 23577621.
• Müller TA, Yu K, Hausinger RP, Meek K (2013). "ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination". PLoS ONE. 8 (6): e67403. doi:10.1371/journal.pone.0067403. PMC 3692455. PMID 23825659.
• Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM (August 2015). "The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond". J. Biol. Chem. 290 (34): 20734–42. doi:10.1074/jbc.R115.656462. PMC 4543635. PMID 26152727.
• Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C, Hübner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV, Höbartner C, Bohnsack MT (October 2016). "NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation" (PDF). EMBO J. 35 (19): 2104–2119. doi:10.15252/embj.201694885. PMC 5048346. PMID 27497299.
• Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (October 2016). "ALKBH1-Mediated tRNA Demethylation Regulates Translation". Cell. 167 (3): 816–828.e16. doi:10.1016/j.cell.2016.09.038. PMC 5119773. PMID 27745969.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.