Acyl-(acyl-carrier-protein)—UDP-N-acetylglucosamine O-acyltransferase

In enzymology, an acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) is an enzyme that catalyzes the chemical reaction

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
Identifiers
EC number2.3.1.129
CAS number105843-69-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are (R)-3-hydroxytetradecanoyl-acyl-carrier-protein and UDP-N-acetylglucosamine, whereas its two products are acyl-carrier-protein and UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl) transferase. Other names in common use include UDP-N-acetylglucosamine acyltransferase and uridine diphosphoacetylglucosamine acyltransferase. This enzyme participates in lipopolysaccharide biosynthesis.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1J2Z, 1LXA, 2AQ9, 2JF2, 2JF3, 2QIA, and 2QIV.

References
    • Anderson MS, Bulawa CE, Raetz CR (1985). "The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli". J. Biol. Chem. 260 (29): 15536–41. PMID 3905795.


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