AZIN2

Antizyme inhibitor 2 (AzI2) also known as arginine decarboxylase (ADC) is an enzyme that in humans is encoded by the AZIN2 gene.[5][6][7]

AZIN2
Identifiers
Aliases	AZIN2, ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
External IDs	OMIM: 608353 MGI: 2442093 HomoloGene: 62172 GeneCards: AZIN2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.1 Start 33,081,104 bp[1] End 33,123,492 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 128,930,233 bp[2] End 128,962,442 bp[2]
Gene ontology Molecular function • putrescine transmembrane transporter activity • catalytic activity • GO:0001948 protein binding • ornithine decarboxylase activator activity • arginine decarboxylase activity • ornithine decarboxylase activity Cellular component • transport vesicle • cytoplasm • mitochondrion • trans-Golgi network • cell projection • Golgi apparatus • cell nucleus • axon • granular vesicle • membrane • dendrite • perinuclear region of cytoplasm • cis-Golgi network • cytoplasmic vesicle • perikaryon • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum-Golgi intermediate compartment • cytosol Biological process • positive regulation of polyamine transmembrane transport • spermatogenesis • putrescine transport • ornithine metabolic process • putrescine biosynthetic process from ornithine • trans-Golgi network membrane organization • agmatine biosynthetic process • GO:0048554 positive regulation of catalytic activity • polyamine biosynthetic process • negative regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	113451	242669
Ensembl	ENSG00000142920	ENSMUSG00000028789
UniProt	Q96A70	Q8BVM4
RefSeq (mRNA)	NM_001293562 NM_001301823 NM_001301824 NM_001301825 NM_001301826 NM_052998 NM_001350398 NM_001350399 NM_001350400 NM_001350401 NM_001350402 NM_001376722 NM_001376724 NM_001376725 NM_001376727 NM_001376729 NM_001376730 NM_001376732	NM_001301841 NM_172875
RefSeq (protein)	NP_001280491 NP_001288752 NP_001288753 NP_001288754 NP_001288755 NP_443724 NP_001337327 NP_001337328 NP_001337329 NP_001337330 NP_001337331 NP_001363651 NP_001363653 NP_001363654 NP_001363656 NP_001363658 NP_001363659 NP_001363661	NP_001288770 NP_766463
Location (UCSC)	Chr 1: 33.08 – 33.12 Mb	Chr 4: 128.93 – 128.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

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External links

• Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser.
• Human AZIN2 genome location and AZIN2 gene details page in the UCSC Genome Browser.

Further reading

• Nagase T, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
• Coleman CS, Hu G, Pegg AE (2004). "Putrescine biosynthesis in mammalian tissues". Biochem. J. 379 (Pt 3): 849–55. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
• Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochem. Biophys. Res. Commun. 328 (1): 206–12. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
• López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". J. Biol. Chem. 281 (41): 30896–906. doi:10.1074/jbc.M602840200. PMID 16916800.
• Tian H, Liu X, Zhang B, Sun Q, Sun D (2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 423–30. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
• Levin VA, Jochec JL, Shantz LM, Aldape KD (2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy". Int. J. Cancer. 121 (10): 2279–83. doi:10.1002/ijc.22914. PMID 17582600.
• Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase". Biochem. J. 409 (1): 187–92. doi:10.1042/BJ20071004. PMID 17900240.

1. GRCh38: Ensembl release 89: ENSG00000142920 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028789 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.
6. Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
7. "Entrez Gene: ADC arginine decarboxylase".