ATF7IP

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.[5][6][7]

ATF7IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPQ
Identifiers
Aliases	ATF7IP, AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
External IDs	OMIM: 613644 MGI: 1858965 HomoloGene: 10051 GeneCards: ATF7IP
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 14,365,632 bp[1] End 14,502,935 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 136,506,167 bp[2] End 136,610,862 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ATPase activity • GO:0001948 protein binding • GO:0001106 transcription corepressor activity Cellular component • cell nucleus • transcription regulator complex • nucleoplasm • cytosol • nuclear body Biological process • positive regulation of transcription, DNA-templated • DNA methylation • regulation of RNA polymerase II transcriptional preinitiation complex assembly • GO:0022415 viral process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of protein stability • protein stabilization • positive regulation of methylation-dependent chromatin silencing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55729	54343
Ensembl	ENSG00000171681	ENSMUSG00000030213
UniProt	Q6VMQ6	Q7TT18
RefSeq (mRNA)	NM_001286514 NM_001286515 NM_018179 NM_181352	NM_019426
RefSeq (protein)	NP_001273443 NP_001273444 NP_060649 NP_851997 NP_060649.3	NP_062299
Location (UCSC)	Chr 12: 14.37 – 14.5 Mb	Chr 6: 136.51 – 136.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ATF7IP has been shown to interact with MBD1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000171681 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030213 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
6. De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215.
7. "Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
8. Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. United States. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN 0270-7306. PMC 152570. PMID 12665582.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
• Fujita N, Watanabe S, Ichimura T, et al. (2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. PMC 152570. PMID 12665582.
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Wang H, An W, Cao R, et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell. 12 (2): 475–87. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ichimura T, Watanabe S, Sakamoto Y, et al. (2005). "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins". J. Biol. Chem. 280 (14): 13928–35. doi:10.1074/jbc.M413654200. PMID 15691849.
• Chang LK, Chung JY, Hong YR, et al. (2005). "Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1". Nucleic Acids Res. 33 (20): 6528–39. doi:10.1093/nar/gki956. PMC 1298921. PMID 16314315.
• Uchimura Y, Ichimura T, Uwada J, et al. (2006). "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation". J. Biol. Chem. 281 (32): 23180–90. doi:10.1074/jbc.M602280200. PMID 16757475.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Human ATF7IP genome location and ATF7IP gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)