ARL8A

ADP-ribosylation factor-like protein 8A is a protein that in humans is encoded by the ARL8A gene.[5][6]

ARL8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZD9, 2H18, 4ILE
Identifiers
Aliases	ARL8A, ARL10B, GIE2, ADP ribosylation factor like GTPase 8A
External IDs	OMIM: 616597 MGI: 1915974 HomoloGene: 23600 GeneCards: ARL8A
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,133,404 bp[1] End 202,144,743 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 135,146,824 bp[2] End 135,156,269 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • alpha-tubulin binding • GTP binding • GO:0001948 protein binding • beta-tubulin binding • GTPase activity Cellular component • cytoplasm • spindle midzone • lysosomal membrane • endosome • lysosome • midbody • extracellular exosome • intracellular • membrane • late endosome membrane • cell membrane • azurophil granule membrane • ficolin-1-rich granule membrane • vacuolar membrane • axon cytoplasm • spindle • cytoskeleton • cell junction • axon • cell projection • synapse Biological process • cell division • small GTPase mediated signal transduction • cell cycle • chromosome segregation • neutrophil degranulation • anterograde axonal transport • protein transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	127829	68724
Ensembl	ENSG00000143862	ENSMUSG00000026426
UniProt	Q96BM9	Q8VEH3
RefSeq (mRNA)	NM_138795 NM_001256129	NM_026823
RefSeq (protein)	NP_001243058 NP_620150	NP_081099
Location (UCSC)	Chr 1: 202.13 – 202.14 Mb	Chr 1: 135.15 – 135.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000143862 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026426 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
6. "Entrez Gene: ARL8A ADP-ribosylation factor-like 8A".

External links

• Human ARL8A genome location and ARL8A gene details page in the UCSC Genome Browser.

Further reading

• Hofmann I, Munro S (April 2006). "An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility". Journal of Cell Science. 119 (Pt 8): 1494–503. doi:10.1242/jcs.02958. PMID 16537643.
• Okai T, Araki Y, Tada M, Tateno T, Kontani K, Katada T (September 2004). "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation". Journal of Cell Science. 117 (Pt 20): 4705–15. doi:10.1242/jcs.01347. PMID 15331635.
• Secombe J, Parkhurst SM (April 2004). "Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein". The Journal of Biological Chemistry. 279 (17): 17126–33. doi:10.1074/jbc.M310097200. PMID 14871887.