ARID4B

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[5][6]

ARID4B
Identifiers
Aliases	ARID4B, BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180, AT-rich interaction domain 4B
External IDs	OMIM: 609696 MGI: 2137512 HomoloGene: 12847 GeneCards: ARID4B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.3 Start 235,131,634 bp[1] End 235,328,219 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A1|13 5.29 cM Start 14,063,232 bp[2] End 14,199,603 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • histone deacetylase activity • molecular function • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • nucleoplasm • cell nucleus • cellular component Biological process • regulation of gene expression by genetic imprinting • regulation of transcription, DNA-templated • establishment of Sertoli cell barrier • regulation of transcription from RNA polymerase II promoter • histone H4-K20 trimethylation • transcription, DNA-templated • histone H3-K9 trimethylation • spermatogenesis • positive regulation of transcription from RNA polymerase II promoter • histone deacetylation • biological process • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51742	94246
Ensembl	ENSG00000054267	ENSMUSG00000039219
UniProt	Q4LE39	A2CG63
RefSeq (mRNA)	NM_001206794 NM_016374 NM_031371	NM_194262 NM_198122
RefSeq (protein)	NP_001193723 NP_057458 NP_112739	NP_919238 NP_937755
Location (UCSC)	Chr 1: 235.13 – 235.33 Mb	Chr 13: 14.06 – 14.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000054267 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039219 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
6. "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".

External links

• Human ARID4B genome location and ARID4B gene details page in the UCSC Genome Browser.

Further reading

• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
• Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
• Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004). "Characterization of BRCAA1 and its novel antigen epitope identification". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. PMID 15247124.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.