ARHGAP9

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.[5][6]

ARHGAP9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2P0D, 2P0H
Identifiers
Aliases	ARHGAP9, 10C, RGL1, Rho GTPase activating protein 9
External IDs	OMIM: 610576 MGI: 2143764 HomoloGene: 13041 GeneCards: ARHGAP9
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,472,264 bp[1] End 57,488,814 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,321,964 bp[2] End 127,329,943 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • lipid binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • cytosol • extracellular region • secretory granule lumen • cytoplasm Biological process • regulation of small GTPase mediated signal transduction • signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • neutrophil degranulation • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64333	216445
Ensembl	ENSG00000123329	ENSMUSG00000040345
UniProt	Q9BRR9	n/a
RefSeq (mRNA)	NM_001080156 NM_001080157 NM_032496 NM_001319850 NM_001319851 NM_001319852 NM_001367422 NM_001367423 NM_001367424 NM_001367425 NM_001367426	NM_001285785 NM_146011 NM_001359656 NM_001359657
RefSeq (protein)	NP_001073625 NP_001073626 NP_001306779 NP_001306780 NP_001306781 NP_115885 NP_001354351 NP_001354352 NP_001354353 NP_001354354 NP_001354355 NP_001306779.1	n/a
Location (UCSC)	Chr 12: 57.47 – 57.49 Mb	Chr 10: 127.32 – 127.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000123329 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040345 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
6. "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

External links

• Human ARHGAP9 genome location and ARHGAP9 gene details page in the UCSC Genome Browser.
• Human RGL1 genome location and RGL1 gene details page in the UCSC Genome Browser.

Further reading

• Peck J, Douglas G, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Letters. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274. S2CID 30443852.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.