ARHGAP4

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.[5][6] It has been shown to regulate cell motility and axonal outgrowth in vitro.[7]

ARHGAP4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EPD
Identifiers
Aliases	ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115, Rho GTPase activating protein 4
External IDs	OMIM: 300023 MGI: 2159577 HomoloGene: 20403 GeneCards: ARHGAP4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,907,367 bp[1] End 153,934,999 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 73,891,442 bp[2] End 73,921,870 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac GTPase binding • GO:0001948 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • identical protein binding Cellular component • cytosol • Golgi apparatus • growth cone • microtubules • cytoplasm Biological process • negative regulation of fibroblast migration • nervous system development • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of cell migration • cytoskeleton organization • Rho protein signal transduction • regulation of small GTPase mediated signal transduction • negative regulation of axon extension • signal transduction • positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	393	171207
Ensembl	ENSG00000089820	ENSMUSG00000031389
UniProt	P98171	n/a
RefSeq (mRNA)	NM_001666 NM_001164741	NM_001162423 NM_001162424 NM_138630
RefSeq (protein)	NP_001158213 NP_001657	n/a
Location (UCSC)	Chr X: 153.91 – 153.93 Mb	Chr X: 73.89 – 73.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000089820 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031389 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (Mar 1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells". Proc Natl Acad Sci U S A. 93 (2): 695–9. doi:10.1073/pnas.93.2.695. PMC 40115. PMID 8570618.
6. "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4".
7. Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). "ARHGAP4 IS A NOVEL RHOGAP THAT MEDIATES INHIBITION OF CELL MOTILITY AND AXON OUTGROWTH". Molecular and Cellular Neurosciences. 36 (3): 332–42. doi:10.1016/j.mcn.2007.07.004. PMC 2111057. PMID 17804252.

External links

• Human ARHGAP4 genome location and ARHGAP4 gene details page in the UCSC Genome Browser.

Further reading

• Tribioli C, Mancini M, Plassart E, et al. (1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae". Hum. Mol. Genet. 3 (7): 1061–7. doi:10.1093/hmg/3.7.1061. PMID 7981673.
• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
• Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID 10655059.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Demura M, Takeda Y, Yoneda T, et al. (2002). "Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus". Hum. Mutat. 19 (1): 23–9. doi:10.1002/humu.10011. PMID 11754100.
• Christerson LB, Gallagher E, Vanderbilt CA, et al. (2002). "p115 Rho GTPase activating protein interacts with MEKK1". J. Cell. Physiol. 192 (2): 200–8. doi:10.1002/jcp.10125. PMID 12115726.
• Foletta VC, Brown FD, Young WS (2003). "Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules" (PDF). Brain Res. Mol. Brain Res. 107 (1): 65–79. doi:10.1016/S0169-328X(02)00448-5. PMID 12414125.
• Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.