ARFRP1

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.[5][6]

ARFRP1
Identifiers
Aliases	ARFRP1, ARL18, ARP, Arp1, ADP ribosylation factor related protein 1
External IDs	OMIM: 604699 MGI: 1923938 HomoloGene: 2425 GeneCards: ARFRP1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,698,642 bp[1] End 63,708,025 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 181,357,690 bp[2] End 181,365,404 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • GTPase activity Cellular component • trans-Golgi network • Golgi apparatus • intracellular • membrane • cytosol • trans-Golgi network membrane Biological process • Golgi to plasma membrane protein transport • retrograde transport, endosome to Golgi • gastrulation • signal transduction • protein localization to Golgi apparatus • intracellular protein transport • protein localization to organelle • small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10139	76688
Ensembl	ENSG00000101246	ENSMUSG00000038671
UniProt	Q13795	Q8BXL7
RefSeq (mRNA)	NM_001134758 NM_001267544 NM_001267545 NM_001267546 NM_001267547 NM_001267548 NM_001267549 NM_003224	NM_001165991 NM_001165992 NM_001165995 NM_029702
RefSeq (protein)	NP_001128230 NP_001254473 NP_001254474 NP_001254475 NP_001254476 NP_001254477 NP_001254478 NP_003215 NP_001254476.1	NP_001159463 NP_001159464 NP_001159467 NP_083978
Location (UCSC)	Chr 20: 63.7 – 63.71 Mb	Chr 2: 181.36 – 181.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.[6]

Interactions

ARFRP1 has been shown to interact with PSCD1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101246 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038671 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem. 270 (51): 30657–63. doi:10.1074/jbc.270.51.30657. PMID 8530503.
6. "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1".
7. Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663.

Further reading

• Zahn C, Hommel A, Lu L, et al. (2007). "Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells". Mol. Membr. Biol. 23 (6): 475–85. doi:10.1080/09687860600840100. PMID 17127620. S2CID 22778359.
• Shin HW, Kobayashi H, Kitamura M, et al. (2005). "Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking". J. Cell Sci. 118 (Pt 17): 4039–48. doi:10.1242/jcs.02524. PMID 16129887.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Behnia R, Panic B, Whyte JR, Munro S (2004). "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p". Nat. Cell Biol. 6 (5): 405–13. doi:10.1038/ncb1120. PMID 15077113. S2CID 22954283.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Coppola T, Magnin-Luthi S, Perret-Menoud V, et al. (2001). "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin". J. Biol. Chem. 276 (35): 32756–62. doi:10.1074/jbc.M100929200. PMID 11438518.
• Bai C, Connolly B, Metzker ML, et al. (2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1230–5. doi:10.1073/pnas.97.3.1230. PMC 15578. PMID 10655513.
• Schürmann A, Schmidt M, Asmus M, et al. (1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D." J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663.

External links

• ARFRP1 human gene location in the UCSC Genome Browser.
• ARFRP1 human gene details in the UCSC Genome Browser.