AKR1C2

Aldo-keto reductase family 1 member C2, also known as bile acid binding protein, 3α-hydroxysteroid dehydrogenase type 3, and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the AKR1C2 gene.[5]

AKR1C2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IHI, 1J96, 1XJB, 2HDJ, 2IPJ, 4JQ1, 4JQ2, 4JQ3, 4JQ4, 4JQA, 4JTQ, 4JTR, 4L1W, 4L1X, 4XO6, 4XO7
Identifiers
Aliases	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD, DD-2, DD/BABP, aldo-keto reductase family 1, member C2, aldo-keto reductase family 1 member C2
External IDs	OMIM: 600450 MGI: 1924587 HomoloGene: 134114 GeneCards: AKR1C2
EC number	1.1.1.357
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 4,987,400 bp[1] End 5,018,031 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 4,574,075 bp[2] End 4,586,541 bp[2]
Gene ontology Molecular function • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity • alditol:NADP+ 1-oxidoreductase activity • phenanthrene 9,10-monooxygenase activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • bile acid binding • carboxylic acid binding • oxidoreductase activity • ketosteroid monooxygenase activity • alcohol dehydrogenase (NADP+) activity • steroid dehydrogenase activity Cellular component • cytoplasm • cytosol Biological process • prostaglandin metabolic process • G-protein coupled receptor signaling pathway • cellular response to jasmonic acid stimulus • steroid metabolic process • positive regulation of protein kinase B signaling • epithelial cell differentiation • daunorubicin metabolic process • doxorubicin metabolic process • lipid metabolism • progesterone metabolic process • digestion • cellular response to prostaglandin D stimulus • positive regulation of cell proliferation • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1646	77337
Ensembl	ENSG00000151632	ENSMUSG00000021207
UniProt	P52895	Q91WR5
RefSeq (mRNA)	NM_001135241 NM_001354 NM_205845 NM_001321027	NM_029901
RefSeq (protein)	NP_001128713 NP_001307956 NP_001345 NP_995317	NP_084177
Location (UCSC)	Chr 10: 4.99 – 5.02 Mb	Chr 13: 4.57 – 4.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3α-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000151632 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021207 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)". National Center for Biotechnology Information, U.S. National Library of Medicine. This article incorporates text from this source, which is in the public domain.

External links

• Human AKR1C2 genome location and AKR1C2 gene details page in the UCSC Genome Browser.